Daily Archives: 7 September 2024

Virginia Tech Scientists Create Tool for Evaluating Optimal Hydration Guidelines

Adequate water consumption is crucial for maintaining human health and overall well-being. However, the global rise in the intake of sugary drinks has contributed to a surge in health-related issues, including obesity, Type 2 diabetes, cardiovascular diseases, and tooth decay. In response to this growing problem, Virginia Tech researchers studied the comprehensiveness and clarity of healthy beverage guidelines in countries that have enacted sugary beverage tax policies between 2000 and 2023. They focused on understanding how well these national dietary guidelines encourage individuals to replace sugary drinks, like sodas, with healthier alternatives, such as water.

To aid governments in promoting healthier hydration practices, the Virginia Tech team developed an innovative tool that assigns a healthy hydration recommendation score. This score is based on clarity, justification, actionability, specificity, and visual content of the guidelines. Governments can use this tool to improve their public health messages, encouraging water consumption while discouraging sugary beverage intake. Drinking water instead of sugary drinks helps reduce the risk of obesity and other serious health problems, making it essential to reinforce clear, actionable hydration guidelines.

Nicole Leary, the lead researcher and a PhD candidate in the Department of Human Nutrition, Foods, and Exercise, emphasised the importance of aligning sugary beverage tax policies with national food-based dietary guidelines that promote water and other nutritious drinks, such as milk and 100 per cent fruit juice. “We examined how robust dietary guidelines could complement other strategies, such as policies, systems, and environmental changes, to help governments promote coherent policies and socially normalise water as the default healthy beverage,” said Leary. The study’s findings demonstrate that robust and clear hydration guidelines can be vital to global health improvement efforts.

The researchers recommend that governments take active steps to develop and promote healthy solid hydration guidelines to mitigate the risks associated with sugary beverage consumption. Among their additional recommendations are ensuring people drink at least eight glasses of water daily, limiting the intake of sugary drinks such as sodas, fruit-flavoured drinks, energy drinks, and sports drinks, and enacting taxes on sugar-sweetened beverages. Such taxes should be earmarked for health promotion programmes and media campaigns encouraging water consumption. They also advise limiting the intake of beverages containing artificial or zero-calorie sweeteners, which are often promoted as healthier alternatives.

This research, recently published in Nutrients and partly funded by Vivica Kraak’s USDA National Institute for Food and Agriculture Hatch Research Project, examined 93 countries implementing sugary beverage taxes by 2023. Of those, 58 countries had food-based dietary guidelines in place, and the researchers found that 48 of these countries had complementary messages that encouraged water consumption while discouraging sugary drinks. The study used a healthy hydration recommendation score of 0 to 12, factoring in message clarity, access, justification, actions, specificity, and visual content.

Countries like Bolivia, Peru, and Brunei scored the highest regarding hydration guidelines, while the United States received a moderate score of 7. The upcoming 2025 edition of the Dietary Guidelines for Americans and the USDA’s MyPlate initiative may strengthen the focus on water consumption across the lifespan, starting at birth and continuing through old age, to support healthy ageing. Associate professor and senior researcher Vivica Kraak stressed the importance of promoting water at every meal, noting that governments should ensure that national dietary guidelines align with sugary beverage tax policies. This research could have significant implications for organisations such as the Food and Agriculture Organization and the World Health Organization in supporting countries to develop culturally adapted, evidence-based dietary guidelines that encourage healthy hydration and normalising clean, safe, and free water as the default beverage.

More information: Nicole Leary et al, An Evaluation of Healthy Hydration Recommendations for 93 Countries with Sugary Beverage Tax Legislation Globally, 2000–2023, Nutrients. DOI: 10.3390/nu16142264

Journal information: Nutrients Provided by Virginia Tech

Semaglutide, a weight loss medication, linked to decreased COVID-19 mortality in Brigham-conducted research

An international study led by Brigham and Women’s Hospital, part of the Mass General Brigham healthcare system, reveals that patients receiving weekly injections of the weight loss drug semaglutide experienced a lower likelihood of death from any cause, including cardiovascular diseases and infections such as COVID-19. This research, known as the SELECT Trial, was supported by Novo Nordisk and examined the impacts of semaglutide compared to placebo on mortality among over 17,000 individuals with heart conditions who were also overweight or obese from October 2018 to March 2023. The findings, which showed a 19% reduction in overall mortality and 15% and 23% decreases in deaths due to cardiovascular issues and other causes, were presented at the 2024 European Society of Cardiology Congress and published concurrently in the Journal of the American College of Cardiology.

Benjamin M. Scirica, MD MPH, the study’s corresponding author and director of quality initiatives at the Cardiovascular Division of Brigham and Women’s Hospital and a Professor of Medicine at Harvard Medical School, expressed surprise at the results. He noted that the trial commenced before the outbreak of COVID-19 and did not initially aim to investigate pandemic-related outcomes. However, the emergence of the pandemic highlighted significant findings, notably that semaglutide not only reduced the risk of cardiovascular deaths but also non-cardiovascular ones, notably those related to COVID-19. This unexpected benefit suggests that this class of drugs might have broader applications than previously thought.

The most frequent non-cardiovascular cause of death among the study participants was infection, with those on semaglutide showing a lower rate of severe complications or fatalities from COVID-19 despite similar infection rates compared to those on placebo. The specific reasons why semaglutide provides these benefits remain unclear, whether they are related to weight loss or other factors. These preliminary observations from a large-scale, multinational study indicate a need for further research to confirm these findings and explore the underlying mechanisms. Upcoming studies will continue to assess how this drug and others in its class can benefit patients beyond their known effects.

More information: Benjamin M. Scirica et al, The Effect of Semaglutide on Mortality and COVID-19–Related Deaths: An Analysis From the SELECT Trial, Journal of the American College of Cardiology. DOI: 10.1016/j.jacc.2024.08.007

Journal information: Journal of the American College of Cardiology Provided by Brigham and Women’s Hospital

Nearly Two-Thirds of UK Adolescents’ Caloric Intake Comes from Ultra-Processed Foods

Recent research from the Universities of Cambridge and Bristol has highlighted that around two-thirds of the daily caloric intake of UK adolescents comes from ultra-processed foods (UPFs). This consumption is notably high among adolescents from socioeconomically deprived backgrounds, those who are white, and younger age groups. Ultra-processed foods use industrial ingredients and methods, often containing additives such as preservatives, sweeteners, colourings, flavourings, and emulsifiers. These foods are typically poor in nutritional quality, featuring high levels of added sugars, saturated fats, and sodium, while low in fibre, protein, and essential micronutrients. UPFs have been identified as significant contributors to the global rise in major health issues, including obesity, type 2 diabetes, and cancer.

The global trends indicate an increase in the availability and sale of UPFs, correlating with a rise in consumption among adolescents. The researchers aimed to understand this pattern in the UK by analysing four-day food diaries of nearly 3,000 adolescents from the UK National Diet and Nutrition Survey from 2008/09 to 2018/19. They found that UPFs constituted an average of 66% of the adolescents’ energy intake during this period, with a slight decrease from 68% in 2008/09 to 63% in 2018/19.

The study also examined how factors such as parental occupation, ethnicity, and regional location within the UK influence UPF consumption patterns. Findings showed that adolescents from less affluent backgrounds consumed a higher percentage of their calories from UPFs than those from wealthier backgrounds. Moreover, non-white adolescents had a lower rate of caloric intake from UPFs compared to white adolescents. Geographical differences were also evident, with those living in North England consuming more UPFs than those in South and London. Additionally, the data suggested a decrease in UPF consumption with age, as 18-year-olds consumed a lower percentage of their calories from UPFs compared to 11-year-olds.

The study’s lead author, Dr Yanaina Chavez-Ugalde from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge, emphasised that many factors, including home environment, marketing, and peer influence, influence adolescent food choices. She highlighted the importance of adolescence as a critical period for forming long-term dietary habits. She noted that the predominant consumption of UPFs is far from ideal, given their potential adverse health impacts.

Dr Esther van Sluijs and Dr Zoi Toumpakari, joint senior authors, noted that UPFs often provide a convenient and cost-effective solution for time- and income-constrained families, albeit at the cost of poor nutritional value. This, they argued, contributes to the observed health disparities across childhood and adolescence. They hope that the insights gained from this study will help policymakers develop more effective interventions to reduce the consumption of UPFs among youth, aiming to mitigate the negative health impacts associated with these foods and improve public health outcomes.

More information: Irazu Yanaina Chavez-Ugalde et al, Ultra-processed food consumption in UK adolescents: distribution, trends, and sociodemographic correlates using the National Diet and Nutrition Survey 2008/09 to 2018/19, European Journal of Nutrition. DOI: 10.1007/s00394-024-03458-z

Journal information: European Journal of Nutrition Provided by University of Cambridge

The Influence of Physical Fitness and Lifestyle on Biological Ageing

“Physical Fitness and Lifestyles Associated with Biological Aging” delves into an increasingly pertinent topic amidst a globally ageing population. The editorial sheds light on the need for a paradigm shift in healthcare strategies—from a traditional disease-oriented approach to more comprehensive interventional strategies targeting the ageing process. This shift is advocated by the burgeoning field of geroscience, which proposes that slowing down the biological mechanisms of ageing could preempt the onset of multiple age-related diseases. This hypothesis is gaining empirical support with advancements in the identification of biomarkers of ageing, driven by progressive improvements in measurement techniques such as various ‘omics’ technologies and analytical methods, including bioinformatics.

The researchers, Takuji Kawamura, Radak Zsolt, Mitsuru Higuchi, and Kumpei Tanisawa from the Faculty of Sport Sciences at Waseda University, along with their colleagues at the Research Center for Molecular Exercise Science at the Hungarian University of Sports Science, highlight the crucial intersection of cardiorespiratory fitness (CRF) and the biological markers of ageing, specifically DNA methylation (DNAm) ageing clocks. They argue for establishing fitness reference values that could serve as benchmarks to help delay the ageing process. The article further discusses findings from their recent study, titled “Associations between cardiorespiratory fitness and lifestyle-related factors with DNA methylation-based ageing clocks in older men: WASEDA’S Health Study.” This study is pivotal as it links quantifiable changes in DNA methylation patterns directly to variations in cardiorespiratory fitness and lifestyle choices among older adults, illustrating how specific lifestyle modifications could alter molecular biomarkers that reflect biological ageing processes.

The significance of their findings is encapsulated in the researchers’ concluding remarks: “Our study reinforces the geroscience concept that active lifestyle choices may impact quantifiable molecular biomarkers that capture biological ageing.” This statement highlights the potential of proactive lifestyle adjustments in influencing biological ageing. It underscores the importance of integrating fitness into daily routines as a strategic approach to extending health span.

Furthermore, the editorial emphasizes the broader implications of these findings for public health policies. By establishing a scientific basis for recommending certain fitness levels and lifestyle choices, policymakers can better design programs that promote healthy ageing among populations. This could lead to reduced healthcare costs associated with age-related diseases and improved quality of life for the elderly. The research serves as a call to action for continued investment in geroscience research to unlock a more comprehensive understanding of the ageing process, which could eventually lead to more effective ageing interventions.

This comprehensive approach to studying ageing opens new avenues for scientific exploration. It offers practical insights that could be translated into everyday health practices and public health strategies, marking a significant step forward in our approach to ageing and longevity.

More information: Takuji Kawamura et al, Physical fitness and lifestyles associated with biological aging, Aging-US. DOI: 10.18632/aging.206031

Journal information: Aging-US Provided by Impact Journals LLC