Monthly Archives: May 2026

Insufficient Protein Consumption May Contribute to Functional Decline with Age

Researchers have found that consuming lower amounts of protein-rich foods may negatively affect physical functioning as people grow older, highlighting the important role protein plays in maintaining muscle strength, mobility, and independence in later life. In a study published in the journal Nutrients, an international team of researchers reported that everyday dietary habits, particularly the regular consumption of protein-rich foods, can influence how well people move and carry out daily activities as they age.

The study was conducted by researchers from the University of Sharjah in the United Arab Emirates, Roskilde University in Denmark, the University of Helsinki in Finland, Shifa Tameer-e-Millat University in Pakistan, King Saud bin Abdulaziz University for Health Sciences in Saudi Arabia, and the Medical University of Vienna in Austria. Led by Dr. Rizwan Qaisar, associate professor of muscle cell physiology at the University of Sharjah, the team analyzed data from more than 38,000 adults aged 50 and older across 27 European countries using information from the Survey of Health, Ageing, and Retirement in Europe. Participants were followed over several years, allowing researchers to examine the relationship between long-term dietary patterns and changes in physical functioning.

The analysis found that adults who regularly consumed lower amounts of protein-rich foods, including eggs, legumes, fish, and poultry, were more likely to experience declines in muscle strength and increasing difficulty performing everyday tasks over time. According to Dr. Qaisar, individuals with consistently low protein intake were more likely to report challenges with activities such as walking short distances, climbing stairs, reaching overhead, and managing routine errands like grocery shopping. These associations were especially apparent among older adults, with some differences observed between men and women.

Functional impairments, including difficulties with walking, maintaining balance, rising from a chair, and climbing stairs, are common consequences of aging. However, the researchers suggest that inadequate protein intake may contribute to these declines. “Simple movements such as walking, standing up, or carrying groceries require muscle strength, balance, and coordination,” said Dr. Qaisar. “When protein intake is low over long periods, the body may struggle to maintain these systems, increasing the risk of functional decline and loss of independence.” The authors noted that declining physical function can reduce quality of life while increasing the risk of falls, hospitalization, and admission to long-term care facilities.

Rather than focusing on supplements or specialized diets, the study examined real-world eating habits and the role of commonly consumed foods such as milk, yogurt, eggs, legumes, fish, and poultry. Because dietary habits can be modified, the findings point to practical opportunities for promoting healthier aging. The researchers suggest that identifying older adults with low protein intake may allow for early, low-cost interventions aimed at preserving strength, mobility, and independence. They noted that while protein’s importance for muscle health is well established, its long-term effects on physical function across different age groups and between men and women have received relatively little attention.

As populations continue to age worldwide, the authors argue that simple lifestyle factors such as daily food choices may play an important role in supporting active and independent living. Their findings showed that lower habitual protein intake was associated with greater odds of reduced handgrip strength and mobility-related limitations among older adults. The relationship between protein intake and handgrip strength was stronger in men, while functional limitations such as difficulty walking 100 metres, stooping, kneeling, reaching above shoulder height, and shopping for groceries were reported more frequently among women. “Altogether, this study demonstrates that lower habitual protein intake is associated with a higher likelihood of short-term incident muscle weakness and functional difficulties among older European adults,” the authors concluded. “These findings suggest that habitual protein intake may play a contributory role in maintaining physical function in aging populations.”

More information: Rizwan Qaisar et al, Low Protein Intake Is Associated with the Risk of Functional Impairment in Older Adults in an Age- and Gender-Specific Manner: A SHARE-Based Study, Nutrients. DOI: 10.3390/nu18071058

Journal information: Nutrients Provided by University of Sharjah

Long-Term Research Indicates Health Problems Emerging Earlier for Younger Generations in the UK

Younger generations in the UK appear to be experiencing poorer health earlier in life than previous generations, according to a review of studies comparing national birth cohort datasets involving tens of thousands of people born since 1946.

The trend, described by researchers as a “generational health drift”, was most consistently observed for obesity and mental ill health. Evidence of worsening diabetes outcomes was also identified when comparing Generation X with Baby Boomers. Drawing on findings from more than 50 studies, the review suggests that more recently born generations may spend a greater proportion of their lives in poor health.

Researchers say improvements in healthcare, screening, or diagnostic practices cannot fully explain the findings. Generational differences were observed for obesity, which does not depend on diagnosis, and for diabetes when objective biomarkers were used. Mental health comparisons were also based on self-reported symptoms of depression and anxiety rather than formal diagnoses.

The research team from University College London, King’s College London, and University of Oxford examined changes in physical and mental health across generations born after the Second World War. Health outcomes were compared across cohorts at similar ages.

The findings, published in the peer-reviewed journal Population Studies, have important implications for future healthcare and social care needs. The authors note that worsening health trends have emerged despite declines in smoking, higher levels of educational attainment, and improved material conditions in early life.

Lead author Laura Gimeno said evidence suggests that more recent generations are experiencing an earlier onset of poor health, particularly obesity and mental ill health. She added that the findings indicate society is not reaching the biological limits of health improvement, but instead seeing the long-term effects of preventable social and environmental exposures.

The researchers warn that the “generational health drift” carries serious implications for policy, planning, and funding as increasing numbers of people live with long-term health conditions. By 2050, one-quarter of the British population is projected to be aged 65 or older, increasing pressures on health and social care systems as well as the wider economy.

Although life expectancy in the UK improved substantially during the twentieth century, gains in healthy life expectancy have slowed or stalled since the early 2010s. According to Professor George Ploubidis, recent declines in healthy life expectancy are likely being driven by worsening mental and physical health among more recent generations. The review included evidence from 51 studies published up to June 2024 covering conditions such as diabetes, high blood pressure, and cancer.

More information: Laura Gimeno et al, The generational health drift: A systematic review of evidence from the British birth cohort studies, Population Studies. DOI: 10.1080/00324728.2026.2652038

Journal information: Population Studies Provided by Taylor & Francis Group

New Research Suggests the Ageing Brain May Be More Resilient and Adaptable Than Previously Thought

A landmark study recently published in the journal Nature Portfolio Scientific Reports suggests that cognitive decline is not an inevitable part of ageing. Researchers from the Center for BrainHealth at The University of Texas at Dallas found that adults ranging in age from 19 to 94 were able to measurably improve their brain performance through ongoing and targeted brain-healthy practices.

The three-year longitudinal study followed nearly 4,000 participants using the BrainHealth Index, a multidimensional tool designed to measure overall brain fitness. Unlike conventional approaches that focus mainly on identifying deficits or disease, the BrainHealth Index evaluates broader aspects of brain health, including thinking skills, social connectedness, emotional balance, and mental resilience.

Researchers observed meaningful improvements in brain health across participants of all ages and performance levels. Even individuals who initially scored among the highest continued to show gains over more than 1,000 days of follow-up, suggesting that the brain may retain the capacity for ongoing optimisation throughout life.

The study also found that participants who entered the programme with the lowest baseline scores experienced some of the greatest rates of improvement. These findings suggest that poorer brain health does not necessarily predetermine future decline and that meaningful progress remains possible even for those starting at a disadvantage.

Improvements were closely linked to consistency and engagement with daily brain-healthy practices. Participants who regularly completed short periods of micro-training lasting between five and fifteen minutes, while also integrating brain-healthy habits into everyday life, achieved the greatest improvements in brain health scores. Benefits were observed equally among younger adults and those in their seventies and eighties, challenging the belief that proactive brain health efforts are only relevant later in life.

The research further highlighted what investigators described as a rebound effect, showing that many participants were able to maintain or even strengthen brain health during major life stressors such as illness, caregiving responsibilities, or job loss. These findings reinforce the idea that brain health is dynamic and adaptable rather than fixed, and that cognitive resilience can be strengthened through intentional strategies and training.

The study was conducted as part of The BrainHealth Project, a long-term research initiative exploring ways to strengthen and optimise brain health across the lifespan. Delivered online and through a mobile app, the programme combines brain strategy training, lifestyle guidance, personalised coaching, and ongoing performance tracking. Researchers say the findings underscore the importance of moving beyond one-size-fits-all approaches and instead supporting personalised pathways that help individuals continually invest in their brain health and cognitive performance throughout life.

More information: Lori Cook et al, Measuring and increasing the brain health span across adulthood: a public health imperative, Scientific Reports. DOI: 10.1038/s41598-026-51403-3

Journal information: Scientific Reports Provided by Center for BrainHealth

The Arts and Healthy Ageing: Evidence of a Slower Ageing Pace

Regular participation in arts and cultural activities such as reading, listening to music, or visiting museums and galleries may help slow the pace of biological ageing, according to a new study by researchers at University College London. Published in the journal Innovation in Aging, the study analysed survey responses and blood samples from 3,556 adults in the UK to examine how arts engagement relates to biological ageing.

Researchers found that people who participated more frequently in arts and cultural activities, and who engaged in a wider range of activities, appeared to have a slower pace of ageing and a younger biological age. These findings were based on chemical changes to DNA known as DNA methylation, which can influence how the body ages without changing a person’s genetic code.

The apparent benefits of arts engagement were similar to those associated with physical activity. People who took part in arts activities at least once a week appeared to age 4% more slowly than those who rarely engaged, a difference comparable to that seen between people who exercised weekly and those who did not exercise at all. The associations were particularly strong among adults aged 40 and older and remained significant after accounting for factors such as smoking, BMI, income, and education.

Lead author Daisy Fancourt said the findings provide biological evidence that arts and cultural engagement can support health in ways similar to exercise. She added that participating in a variety of activities may be especially beneficial because different forms of art may offer physical, cognitive, emotional, and social stimulation.

Senior author Feifei Bu noted that the study adds to growing evidence linking the arts to improved health outcomes, including reduced stress, lower inflammation, and better cardiovascular health. The researchers used seven “epigenetic clocks” to estimate biological age and pace of ageing by examining age-related DNA changes. The newest tools, DunedinPoAm and DunedinPACE, were the most sensitive in detecting links between arts engagement and slower ageing.

Using the DunedinPACE measure, engaging in arts activities at least three times a year was linked to 2% slower ageing, monthly participation to 3% slower ageing, and weekly participation to 4% slower ageing compared to infrequent engagement. Another measure, PhenoAge, found that people who participated in arts and cultural activities weekly were biologically about one year younger on average than those who rarely engaged. Older epigenetic measures did not detect similar associations, which researchers suggested may reflect their lower sensitivity to age-related decline.

More information: Daisy Fancourt et al, Does leisure activity matter for epigenetic aging? Analyses of arts engagement and physical activity in the UK Household Longitudinal Study, Innovation in Aging. DOI: 10.1093/geroni/igag038

Journal information: Innovation in Aging Provided by University College London

Daily Rest-Activity Patterns Correlate with the Pace of Biological Ageing

Adults with stronger and more consistent daily patterns of rest and activity may experience slower biological aging, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health. The researchers found that individuals with clearer distinctions between daytime activity and nighttime rest, less fragmented daily rhythms, and more stable day-to-day patterns showed signs of being biologically younger based on blood-test measures of physiological aging.

The study analyzed data from 207 adults participating in the long-running Baltimore Epidemiologic Catchment Area cohort study. Participants wore wrist-based actigraphy devices for approximately seven consecutive days to measure their rest-activity rhythms. Researchers then compared these data with four established epigenetic “clocks” derived from blood samples—Horvath, Hannum, PhenoAge, and GrimAge—which estimate physiological aging based on DNA-related biological markers.

The findings showed that stronger and more regular rest-activity rhythms were significantly associated with lower physiological age scores, particularly on the GrimAge and PhenoAge measures. These relationships remained significant after accounting for chronological age and other factors such as sex, education, and health conditions. The associations appeared stronger among women and white participants.

The study’s co-senior author, Adam Spira, said the findings suggest that rest-activity rhythms could become useful indicators of physiological aging and may eventually serve as targets for interventions aimed at slowing the aging process. Co-senior author Brion Maher noted that the results may actually underestimate the true association because the study involved older adults who had survived and remained healthy enough to participate. Lead author Chunyu Liu emphasized the need for future longitudinal studies to determine whether disrupted rhythms contribute to accelerated aging or result from it.

Scientists have increasingly used wearable devices to monitor rest-activity rhythms in everyday life. Previous research has linked weaker and more fragmented rhythms to brain atrophy, mild cognitive impairment, dementia, psychiatric disorders, and certain cancers. Although rest-activity rhythms naturally weaken with age, chronological age alone may not fully reflect biological decline, which can also be influenced by factors such as inflammation, high blood sugar, and smoking.

The researchers hope future studies and clinical trials will determine whether strengthening and stabilizing daily rest-activity rhythms can help slow physiological aging. They also anticipate that wearable technologies may eventually allow older adults and clinicians to monitor biological aging and related health risks more easily in routine daily life.

More information: Chunyu Liu et al, Twenty-Four–Hour Rest-Activity Rhythms and Epigenetic Age Acceleration in Middle-Aged and Older Adults, JAMA Network Open. DOI: 10.1001/jamanetworkopen.2026.11474

Journal information: JAMA Network Open Provided by Johns Hopkins Bloomberg School of Public Health

The Upside of Ageing: Regret May Fade Over Time

Older adults tend to report fewer recent regrets than younger adults, according to research published by the American Psychological Association. While people of different ages reported a similar number of long-term regrets, older adults experienced less anger and frustration when reflecting on past mistakes and missed opportunities. The findings suggest that both age and time influence how people emotionally process regret.

“Regrets are incredibly common. Almost all of us experience big regrets in our personal and professional lives – from marrying the wrong person to never finishing college,” says lead author Julia Nolte of Tilburg University. “The good news is that for many of us, the experience of regret seems to become less negative with age.” The study was published in the journal Emotion.

The researchers surveyed 90 U.S. adults between the ages of 21 and 89. Participants listed up to five recent regrets from the past year and five long-term regrets. They then described and rated their most significant recent and long-term regrets, including the emotions involved, how controllable the situations felt, and how they were coping with them. Older adults reported fewer and less emotionally intense recent regrets and were more likely to regret missed opportunities rather than wrong actions.

According to Nolte, more research is needed to understand why aging changes the experience of regret and whether some differences reflect generational experiences rather than age itself. Future studies may also examine whether regret serves different psychological purposes across the lifespan. “It is assumed that regret helps us make better choices moving forward,” Nolte says. “But older adults may derive other benefits from regret, such as a chance to reflect or look for meaning.”

More information: Julia Nolte et al, Adult age differences in the response to and regulation of recent versus long-term regrets, Emotion. DOI: 10.1037/emo0001672

Journal information: Emotion Provided by American Psychological Association

Healthy Ageing in the Digital Era

As Australia and many countries around the world experience rapidly ageing populations, technology is increasingly viewed as a solution to help older adults live safely, independently and well. However, a new study led by researchers at Flinders University warns that innovation alone is not enough. The paper, published in the international journal Digital Health, argues that without thoughtful design, ethical safeguards and meaningful involvement of older people, technology may fail to support those it is intended to help.

The study explores how smart technologies such as home sensors, wearable devices and artificial intelligence can support healthy aging while protecting dignity, autonomy and human connection. According to lead author Dr Claire Gough, the conversation about ageing and technology must move beyond the assumption that new devices automatically improve care. She emphasises that technology is not simply about devices, but also about people, relationships, values and the environments in which older adults live.

Smart technologies can provide important benefits. Devices that detect falls, monitor routines or support medication reminders may help older adults remain in their homes longer while providing reassurance to families and caregivers. Virtual assistants and personalised applications may also encourage physical activity, healthy eating and social engagement. Despite these potential advantages, adoption among older adults remains lower than expected.

Researchers found that one major barrier is that many technologies are developed without fully understanding the lived experiences of ageing. Older adults often express concerns about privacy, loss of control and constant monitoring within their homes. Dr Gough notes that if technology feels intrusive or disrespectful, people are unlikely to embrace it, regardless of how advanced it may be. The study also highlights that decisions about technology are often influenced by families, caregivers and healthcare professionals, particularly when systems are difficult to use or create ethical concerns.

The paper further examines how homes are evolving into digitally connected environments where information may be continuously collected and shared. While these systems can improve safety, they may also alter feelings of comfort, autonomy and privacy within the home. Researchers stress the importance of asking critical questions about who controls data, who can access it and how it is ultimately used. The authors strongly advocate for co-design approaches that involve older adults from the earliest stages of development to ensure technologies are practical, respectful and culturally appropriate.

The study concludes that technology should enhance rather than replace human care. Nurses, care workers and families play a critical role in helping older adults use digital tools effectively, and education in digital skills and ethics is essential. The authors also call for stronger policy support, improved affordability and greater digital inclusion, particularly in rural communities. Dr Gough emphasises that the future of ageing is not only a technological challenge, but a human one, and that dignity, choice and equity must remain at the centre of innovation to support healthy ageing in the digital era.

More information: Claire Gough et al, Beyond innovation: Reimagining inclusive and ethical technologies for ageing populations, Digital Health. DOI: 10.1177/20552076261418907

Journal information: Digital Health Provided by Flinders University

Scientists Design “Ageing Clocks” to Predict Age-Related Decline

Ageing is a complex biological process, and accurately measuring how the body declines over time has long challenged scientists. People of the same chronological age can experience very different health trajectories, making it difficult to determine biological age and identify the true drivers of ageing. To address this, researchers from China’s Aging Biomarker Consortium (ABC) developed a computational framework called the Digital Aging Twin to predict biological age and track how different organs age over time.

The study, published in the journal Cell on May 8, involved researchers from the Chinese Academy of Sciences, Capital Medical University, and several other institutions. The team recruited 2,019 healthy participants aged 18 to 91 from multiple Chinese cities to establish a standardized multicentre cohort known as mCAS (multicentric Chinese Aging Standardized). Researchers gathered more than 240 physiological and molecular measurements from each participant, including clinical tests, brain and retinal imaging, cognitive and motor assessments, DNA methylation, proteins, metabolites, and gut microbiome data.

Using more than one billion high-quality data points, the researchers created a three-tier system of “ageing clocks.” The first tier, called the core capacity clock, integrates 240 physiological indicators to measure overall functional decline. The second tier, the multimodal clock, combines multiple layers of molecular data using deep-learning methods to estimate biological age with high accuracy, achieving a mean absolute error of only 3.87 years. The third tier consists of organ-specific clocks for organs such as the brain, liver, lungs, muscles, blood vessels, and skin.

One of the study’s most notable findings was that organs age at different rates. Researchers discovered that the liver reaches a major ageing turning point around age 40, while the brain’s ageing accelerates closer to age 50. The analysis also revealed two major waves of ageing-related change: one between ages 40 and 50 and another between ages 60 and 70. These findings suggest that ageing is not a uniform process but occurs in distinct phases across different organ systems.

To investigate the biological drivers of ageing, the researchers examined plasma proteins, human liver tissue, cultured human cells, and animal models. They identified liver-derived coagulation factors — particularly F13B, F9, and F10 — as direct contributors to vascular and systemic ageing. Experiments showed that exposing human vascular cells to these factors triggered signs of cellular senescence and inflammation, while injecting F13B into mice accelerated ageing across multiple tissues, including the liver, heart, kidneys, and blood vessels.

The researchers also developed simplified “proxy clocks” based on just 100 to 108 plasma proteins, raising the possibility that future blood tests could provide comprehensive ageing assessments. The study further identified lifestyle factors associated with slower biological ageing, including greater fruit intake, regular sleep schedules, and moderate walking, while smoking, poor sleep, and frequent eating were linked to accelerated ageing. Although the framework currently relies on cross-sectional data, researchers say the Digital Aging Twin represents a major shift in ageing science — from simply describing ageing to predicting it and identifying actionable biological drivers that could guide future interventions.

More information: Jiaming Li et al, Multimodal clocks of human aging, Cell. DOI: 10.1016/j.cell.2026.04.025

Journal information: Cell Provided by Chinese Academy of Sciences Headquarters

New Research Questions Long-Held Beliefs About the Harms of “Yo-Yo Dieting”

Weight loss followed by weight regain, commonly referred to as “yo-yo dieting” or weight cycling, has long been viewed as harmful to health, with some experts suggesting it may even be worse than remaining overweight. However, a new analysis published in The Lancet Diabetes & Endocrinology challenges this widely accepted belief, concluding that there is little convincing evidence that weight cycling itself causes long-term harm in people living with obesity.

In an invited Personal View article, Professors Faidon Magkos from the University of Copenhagen and Norbert Stefan from the German Center for Diabetes Research (DZD), University Hospital Tübingen, and Helmholtz Munich reviewed decades of evidence from human and animal studies examining the effects of repeated weight loss and regain. After evaluating observational studies, randomized clinical trials, and experimental research, the authors concluded that many concerns surrounding weight cycling appear overstated and are not strongly supported by causal scientific evidence.

For years, weight cycling has been associated with a variety of negative health outcomes, including increased fat accumulation, accelerated muscle loss, slower metabolism, and greater risks of diabetes and cardiovascular disease. These concerns have shaped public messaging and clinical discussions about obesity, sometimes leading individuals to believe that repeated attempts to lose weight may ultimately “do more harm than good.” According to the authors, however, much of the evidence supporting these claims has important limitations.

“Many people struggling with weight are discouraged from trying to lose weight because they fear ‘yo-yo dieting’ will damage their metabolism or lead to muscle loss,” says Prof. Magkos. “Our review suggests these fears are largely unsupported. In most cases, the potential benefits of attempting weight loss clearly outweigh the theoretical risks associated with weight cycling.”

The researchers note that many observational studies fail to adequately account for factors such as aging, pre-existing illness, smoking, and the cumulative effects of obesity itself. Once these variables are properly considered, the apparent harmful associations linked to weight cycling often weaken substantially or disappear altogether. “Higher levels of body fat remain the primary driver of metabolic disease risk,” explains Prof. Stefan. “Weight fluctuation alone does not appear to independently worsen long-term health outcomes in a meaningful way.”

Importantly, studies using objective measurements of body composition show little evidence that repeated weight loss and regain lead to disproportionate reductions in lean muscle mass or persistent suppression of metabolic rate. In many cases, individuals who regain lost weight return to a body composition similar to where they started, rather than ending up in a metabolically worse state. The authors also found no robust evidence that weight cycling itself causes the gradual increase in body weight commonly observed over time in people with obesity.

The analysis does acknowledge that weight regain can reverse many of the health improvements achieved during weight loss, including better blood sugar control, lower blood pressure, and improved cholesterol levels. However, the authors stress that losing these benefits is not the same as causing additional harm. “Regaining weight generally brings people back toward their baseline level of risk, not beyond it,” says Magkos. “There is an important distinction between reversing benefits and actively damaging health.”

The findings are particularly relevant as highly effective anti-obesity medications such as GLP-1 receptor agonists and dual incretin therapies become increasingly common. These treatments can produce substantial weight loss, but significant regain often occurs when medication is stopped, creating a pattern similar to weight cycling. The authors argue that this should not automatically be interpreted as harmful. Even temporary periods of reduced weight may provide meaningful improvements in metabolic health, physical functioning, and quality of life. Overall, Magkos and Stefan conclude that people living with overweight or obesity should not be discouraged from pursuing weight loss, even when long-term maintenance remains challenging. “The idea that ‘yo-yo dieting ruins your metabolism’ is not supported by robust evidence,” they state. “Trying — and even failing — to lose weight is not harmful. But giving up altogether may be.”

More information: Faidon Magkos et al, Is weight cycling clinically harmful? The Lancet Diabetes & Endocrinology. DOI: 10.1016/S2213-8587(26)00037-9

Journal information: The Lancet Diabetes & Endocrinology Provided by Deutsches Zentrum fuer Diabetesforschung DZD

Study Reveals How Gut Changes with Age May Drive Disease Risk

Researchers at the Marshall University Joan C. Edwards School of Medicine have uncovered new evidence suggesting that microscopic particles produced in the gut may contribute to inflammation and chronic diseases associated with aging. The findings provide new insight into the complex connections between sleep, metabolism and immune health.

Published in April 2026 in the Aging Cell, the study focused on gut luminal exosomes — tiny particles that enable cells to communicate by transporting proteins and genetic material throughout the body. Researchers discovered that exosomes from older animals carried molecular signals linked to insulin resistance, inflammation and disruption of the gut barrier. When these exosomes were transferred to younger animals, they triggered similar biological effects. In contrast, transferring exosomes from younger animals to older animals appeared to lessen several metabolic features associated with aging. The findings highlight the potential role of the gut ecosystem in the development of age-related diseases.

The study suggests that these exosome particles may directly influence disease development. As the gut barrier weakens with age, inflammatory substances may leak into the bloodstream, potentially contributing to chronic inflammation and increasing the risk of cardiovascular and metabolic diseases.

“This study helps clarify how the physiological stressors associated with biological aging may accelerate processes linked to aging and disease,” said Abdelnaby Khalyfa, professor of biomedical sciences at the Joan C. Edwards School of Medicine and lead author of the study. “Understanding these mechanisms is essential to identifying new targets for intervention and improving long-term outcomes for patients.”

The research also reinforces the idea that aging affects multiple body systems simultaneously, including metabolism, immune function and cellular signalling. In addition, the team identified specific molecules within the exosomes that may help researchers better understand, detect and eventually treat age-related diseases. The findings may also have implications for chronic conditions characterized by ongoing physiological stress, where disease pathways may overlap with mechanisms involved in biological aging.

More information: Abdelnaby Khalyfa et al, Gut Luminal Exosomes in Young and Old Mice: Multi-Omic Characteristics and Regulation of Gut Permeability, Aging Cell. DOI: 10.1111/acel.70455

Journal information: Aging Cell Provided by Marshall University Joan C. Edwards School of Medicin

Participating in Nature-Based Groups Enhances Wellbeing in Older Adults Experiencing Social Isolation

Nature-based group activities can help reduce loneliness, improve sleep and cognitive function, and strengthen feelings of connection to nature among older adults living in care homes. Activities centred on outdoor experiences and engagement with the natural environment promoted wellbeing and health through peer interaction and meaningful shared experiences.

“Participating in weekly group activities for just nine weeks was enough to reduce loneliness and improve sleep, memory, and participants’ sense of connection to nature,” says Kaisu Pitkälä, Director of the Department of General Practice and Primary Health Care at the University of Helsinki. “Our findings also underscore the importance of providing older adults in care homes with more opportunities to spend time outdoors and engage with nature.”

The researchers were encouraged by the positive outcomes, particularly because many participants were frail, living with multiple chronic conditions, and faced logistical challenges related to outdoor activities. Excursions often required accessible taxis, and all participants travelled in wheelchairs. According to Pitkälä, extending the duration of the intervention could have produced even greater benefits.

As part of the project, researchers trained 52 group facilitators working in Helsinki care homes, helping to expand and sustain nature-based practices in residential care settings.

“Frail older adults possess significant personal strengths and resources, and supporting these can improve their wellbeing and overall health,” Pitkälä explains. “More than half of care home residents experience loneliness, which poses risks to health and memory comparable to smoking or obesity. Loneliness is often invisible, which is why it is important to ask older adults directly about their experiences.”

The intervention was based on the Circle of Friends programme developed by the Finnish Association for the Welfare of Older People, which has involved more than 13,000 participants across over 100 municipalities. Notably, 65% of the groups continued independently after the formal programme ended.

Pitkälä describes the study as an important contribution to research on non-pharmacological approaches for frail older adults, particularly those with memory impairment living in 24-hour care settings. The study included 319 older adults living in care homes who experienced loneliness, with an average age of 83 years. Slightly more than half of the participants had memory disorders. Participants were randomly assigned either to take part in the nature-based group activities or to a comparison group.

More information: Kaisu Pitkälä et al, Effects of Nature-based Group Intervention on Cognition and Nature Connectedness Among Lonely Older Adults Living in Assisted Living Facilities—Secondary Analyses of an RCT, Journal of the American Medical Directors Association. DOI: 10.1016/j.jamda.2026.106203

Journal information: Journal of the American Medical Directors Association Provided by University of Helsinki

Researchers Explore Garlic Compound’s Role in Maintaining Muscle Health

Researchers are exploring whether a natural compound found in aged garlic extract could help support muscle health as people grow older. A new study suggests that S-1-propenyl-L-cysteine, or S1PC, may help improve muscle strength and reduce frailty during aging. The findings offer hope for a simple nutrition-based approach that could help older adults stay active and maintain physical function later in life.

The study was conducted by researchers from the Institute for Research on Productive Aging and Wakunaga Pharmaceutical, a company known for developing products made from aged garlic extract. Their research will be published in the journal Cell Metabolism on May 7, 2026. The researchers wanted to understand better how natural compounds from food might help reduce some of the physical decline commonly linked to aging.

As people age, many experience a gradual loss of muscle strength, lower energy levels, and increased frailty, even when they do not have a serious medical condition. These changes can make everyday activities more difficult and reduce the quality of life. Researchers say that while some treatments for age-related conditions can be expensive, there is growing interest in finding safer and more affordable ways to support healthy aging. Natural health products and nutrition-based approaches are becoming increasingly important, but many still lack strong scientific evidence. This study aimed to help fill that gap.

The research team focused on S1PC, a compound naturally found in aged garlic extract. They discovered that the compound appears to help different parts of the body communicate with each other in ways that support muscle function. Instead of acting directly on muscles, the compound seems to influence signals between fat tissue and the brain. These signals may help the body better regulate muscle strength, energy use, and body temperature during aging. The researchers describe this as an important new pathway connecting fat tissue, the brain, and muscles.

To better understand the effects of S1PC, the team studied aged mice over a longer period of time. The mice that received the compound showed stronger muscle performance, lower frailty scores, and healthier body temperature regulation compared with untreated mice. The researchers also conducted a small human study and found that people who took S1PC showed increases in certain blood markers linked to healthy cellular function. The effects appeared to be more noticeable in people who had enough body fat, suggesting that fat tissue may play an important role in how the compound works in the body.

Dr. Kiyoshi Yoshioka, one of the study’s lead authors, said his experiences working with older adults inspired the research. He explained that many seniors lose strength and independence even without having a major illness, leaving limited options for prevention. Another senior researcher, Dr. Shin-ichiro Imai, said the findings reveal a new way organs may work together during aging and could open the door to future anti-aging strategies. Although more human research is still needed, the researchers believe S1PC may eventually become part of a simple daily nutritional approach to help older adults maintain strength, mobility, and overall well-being.

More information: Jun-ichiro Suzuki et al, Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling, Cell Metabolism. DOI: 10.1016/j.cmet.2026.04.006

Journal information: Cell Metabolism Provided by Institute for Research on Productive Aging