Author Archives: support

Quick Five-Minute Assessment Enhances Dementia Care in Primary Settings

The challenge of underdiagnosing dementia, particularly among Black and Hispanic populations, remains a significant issue in healthcare. A groundbreaking study recently published in Nature Medicine introduces a straightforward, five-minute test that, combined with tailored recommendations integrated into electronic medical records, has led to a threefold increase in the diagnosis and management of dementia in a primary care setting compared to a control group. This new method, known as the “5-Cog paradigm,” was developed by experts at the Albert Einstein College of Medicine and the Montefiore Health System. It has markedly improved the identification and initial treatment of mild cognitive impairment and dementia.

Joe Verghese, M.B.B.S., the study’s senior author and the creator of the 5-Cog paradigm, highlighted the persistent issue of undiagnosed dementia within primary care environments, noting that even when it is identified, it often remains untreated. He explained that traditional methods for detecting cognitive impairment are time-consuming and costly and generally require a neurologist’s involvement. Moreover, since existing assessments were primarily designed for white populations, they fail to accommodate cultural nuances. The 5-Cog paradigm was designed to overcome these limitations, offering a culturally sensitive, efficient, and cost-effective diagnostic tool.

Dr Verghese, a professor and director of the division of cognitive and motor ageing at the Saul R. Korey Department of Neurology and several other prestigious positions at Einstein and Montefiore, alongside Emmeline Ayers, M.P.H., who is the last author of the paper and a principal staff scientist in the department, have significantly contributed to this advancement. The 5-Cog assessment includes a picture-based memory impairment screening, a symbol-matching task, and verification of cognitive complaints by the patient, making it a tool that can be effectively administered by minimally trained non-physician personnel. These staff members can then quickly relay critical information to primary care providers.

The research encompassed 1,201 older adults from socioeconomically disadvantaged neighbourhoods in the Bronx, with a median age of 72.8, most of whom were Black or Hispanic/Latino. Participants were randomly assigned to receive the 5-Cog assessment or placed in a control group without testing. Results from a 90-day follow-up showed that individuals assessed with the 5-Cog paradigm were three times more likely to experience enhanced dementia care actions. These included receiving new diagnoses of mild cognitive impairment or dementia, referrals to specialists, and appropriate medication.

Dr. Verghese expressed optimism that the study’s findings could lead to significant changes in primary care practices, enhancing the diagnosis and treatment of older individuals with mild cognitive impairment or dementia. This advancement promises to improve the quality of life for many patients and reduce the long-term healthcare burdens associated with untreated mental disorders.

More information: Joe Verghese et al, Non-literacy biased, culturally fair cognitive detection tool in primary care patients with cognitive concerns: a randomized controlled trial, Nature Medicine. DOI: 10.1038/s41591-024-03012-8

Journal information: Nature Medicine Provided by Albert Einstein College of Medicine

Unveiling the Role of B12 Deficiency in Inflammation: A Hidden Trigger Revealed

Vitamin B12 is an indispensable nutrient crucial for various physiological processes. It is pivotal in maintaining overall health. Its deficiency often stems from inadequate dietary intake, particularly among vegetarian and vegan populations, or poor absorption within the body. This deficiency can lead to a spectrum of complications, including significant neurological disorders. While previous research has hinted at vitamin B12’s potential anti-inflammatory properties, the exact nature of this relationship still needs to be understood.

Recently, a team of researchers from Spain embarked on a study investigating how vitamin B12 impacts levels of key inflammatory molecules in the body, specifically interleukin (IL)-6 and C-reactive protein (CRP). Rosa M. Lamuela-Raventós, co-corresponding author and Professor of Nutrition, Food Sciences and Gastronomy at INSA-University of Barcelona, and Inés Domínguez López, a predoctoral researcher at the University of Barcelona and co-first author, explained the motivations behind their research.

“Chronic inflammation is a key player in a wide array of diseases. Gaining a deeper understanding of how vitamin B12 status influences inflammation could have far-reaching implications for disease prevention and management,” Domínguez López stated. IL-6 and CRP are widely recognized markers of inflammation in clinical settings, with elevated levels linked to various inflammatory conditions and chronic diseases. Establishing the connection between these inflammatory markers and vitamin B12 levels could provide crucial insights for developing novel therapeutic strategies.

The study drew upon samples from a subset of participants in PREDIMED, a large clinical trial in Spain evaluating the Mediterranean diet’s impact on cardiovascular disease prevention. Analysis of serum vitamin B12 levels and inflammatory marker concentrations revealed a notable correlation. Marta Kovatcheva, a co-first author and postdoctoral researcher at the Institute for Research in Biomedicine (IRB Barcelona), elaborated, “Our findings indicate that higher vitamin B12 levels generally correspond to lower inflammatory marker levels—a relationship we describe as inverse.”

Kovatcheva underscored the novelty of the study, which did not specifically target individuals with vitamin B12 deficiency but revealed significant implications. “Our findings present a new perspective on the consequences of vitamin B12 deficiency. While its harmful effects are well-documented, our study uncovers a novel relationship that illuminates previously unexplained symptoms, such as neurological defects associated with B12 deficiency.”

Domínguez López stressed the importance of expanding research cohorts to validate their findings across broader populations. “Future studies should consider sex-specific differences and investigate specific conditions like B12 deficiency, infection, or aging in humans,” she suggested.

In addition to human studies, the research team explored similar associations between vitamin B12 and inflammatory markers in naturally ageing mice. This parallel investigation offers insights into underlying biological mechanisms governing the inverse correlation. “Understanding the biological basis of our findings in mice could inform dietary and clinical recommendations for humans in the future,” noted Lamuela-Raventós.

Interestingly, the researchers noted a difference between humans and mice concerning B12 deficiency with age. “Unlike humans, mice do not typically become B12 deficient as they age,” Kovatcheva remarked. This observation suggests that studying mouse models could offer insights into preventing B12 deficiency in older adults.

Looking to the future, the team is eager to explore the vitamin B12-inflammation link within specific high-inflammation conditions such as infection, obesity, and irritable bowel syndrome. “Investigating whether vitamin B12 supplementation can play a role in managing these conditions is a promising direction for future research,” Lamuela-Raventós commented, emphasizing the potential practical applications of their findings.

The study underscores vitamin B12’s multifaceted role in health, particularly its potential to modulate inflammation—a pivotal factor in numerous chronic diseases. By elucidating these connections, the research opens doors to innovative approaches for disease prevention and therapeutic interventions centred around optimizing vitamin B12 status.

More information: Inés Domínguez-López et al, Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice, Journal of the Science of Food and Agriculture. DOI: 10.1002/jsfa.12976

Journal information: Journal of the Science of Food and Agriculture Provided by Society of Chemical Industry

Study: Surgery for Hip Fractures Linked to Longer Life in People with Dementia

The decision-making process for individuals with dementia contemplating surgery is multifaceted, influenced not only by cognitive limitations but also by the critical role of post-operative rehabilitation in ensuring successful outcomes. A recent study conducted by researchers from Brigham and Women’s Hospital, part of the Mass General Brigham healthcare system, focused on assessing the treatment outcomes of hip fractures in dementia patients, comparing surgical versus non-surgical approaches to aid healthcare decision-making. Published in JAMA Network Open, the study revealed that surgically treated patients had lower mortality rates, particularly when fractures occurred in the head and neck of the femur.

Lead author Rachel Adler, ScD, RD, a research scientist at the Center for Surgery and Public Health, highlighted the study’s aim to enhance understanding of surgical decision-making in dementia patients, noting the high incidence of hip fractures among older adults. The findings underscored the importance of considering outcomes that matter to patients and caregivers when weighing the surgery option.

In this retrospective cohort study, data from 56,209 Medicare patients with dementia living independently in the community were analysed, focusing on those who sustained hip fractures between January 2017 and June 2018. Of these patients, 59% underwent surgical treatment, while 41% were managed non-surgically. The study stratified results by dementia severity and fracture location, examining mortality rates at 30, 90, and 180 days post-surgery. The analysis revealed significantly lower mortality odds in surgically managed cases where fractures occurred in the head and neck of the femur, the most prevalent type of hip fracture, across both moderate-to-severe and mild dementia stages.

Interestingly, patients with fractures in other hip locations did not demonstrate similar mortality benefits from surgical intervention. Additionally, the study found that patients with moderate-to-severe dementia undergoing surgery were more prone to experiencing delirium during their hospital stay compared to their non-surgical counterparts. Notably, there was no significant difference in nursing home admissions between surgically and non-surgically managed patients.

Adler and her team plan to extend their research to explore long-term patient-reported outcomes in dementia patients. This will encompass pre- and post-operative periods across various surgical interventions and treatments for other health conditions. This longitudinal approach aims to deepen understanding of how healthcare decisions impact the quality of life in dementia patients.

The study’s implications are crucial for clinicians caring for dementia patients in community settings. It offers valuable insights that can facilitate informed discussions with patients and their caregivers regarding treatment options aligned with individual quality-of-life goals. Adler emphasised the significance of these findings in guiding clinical practice and enhancing patient-centred care for this vulnerable population.

More information: Rachel R. Adler et al, Hip Fracture Treatment and Outcomes Among Community-Dwelling People Living With Dementia, JAMA Network Open. DOI: 10.1001/jamanetworkopen.2024.13878

Journal information: JAMA Network Open Provided by Brigham and Women’s Hospital

Early Management of Blood Pressure in Acute Stroke: Balancing Benefits and Risks

New research highlighted at the 10th European Stroke Organisation Conference in Basel, Switzerland and concurrently published in the New England Journal of Medicine underscores the importance of early stroke type identification in maximising the benefits of immediate in-ambulance blood pressure reduction for suspected acute stroke patients. Professor Craig Anderson, Director of Global Brain Health at The George Institute for Global Health and lead researcher, emphasised the potential of this study to pave the way for improved outcomes, particularly in the context of the most severe stroke cases.

“Our findings demonstrate significant advantages in administering early blood pressure-lowering treatment to patients with intracerebral haemorrhage during ambulance transit. However, for patients ultimately diagnosed with ischaemic stroke, this intervention appeared to exacerbate outcomes. Hence, accurate early diagnosis is pivotal in harnessing the benefits of very early blood pressure management,” Professor Anderson explained.

The Intensive Ambulance-Delivered Blood Pressure Reduction in Hyper-Acute Stroke Trial (INTERACT4) study encompassed a multicentre, randomised, open-label, blinded-outcome investigation conducted across numerous ambulance services in China. Over 2,400 patients with suspected acute stroke and elevated systolic blood pressure (≥150mmHg), assessed within two hours of symptom onset, were randomly assigned to either immediate pre-hospital blood pressure reduction (target 130-140mmHg) or standard in-hospital blood pressure management.

Notably, the group receiving pre-hospital blood pressure reduction for haemorrhagic stroke showed a 30% reduction in the likelihood of poor functional outcomes compared to those managed conventionally upon hospital arrival. Conversely, patients diagnosed with cerebral ischaemia experienced a 30% higher likelihood of poor functional outcomes with early blood pressure-lowering treatment. Overall, the intervention’s impact on functional outcomes balanced across all stroke types, with similar rates of serious adverse events observed between groups.

Ischaemic strokes, responsible for approximately 80% of all strokes worldwide, result from a blockage in a blood vessel, leading to restricted blood flow and subsequent neurological impairment. On the other hand, intracerebral haemorrhage (ICH), accounting for more than a quarter of stroke cases, involves bleeding within the brain tissue and is particularly lethal, especially in regions like China, where the study was conducted.

“All acute stroke treatments hinge heavily on time sensitivity – brain cells rapidly deteriorate without oxygen. However, determining the optimal treatment approach before identifying the stroke type remains challenging without advanced brain imaging,” Professor Anderson remarked. “While our results do not advocate for in-ambulance blood pressure management for all suspected acute stroke patients, the advent of mobile stroke units equipped with CT scanners and diagnostic tools holds promise for early identification of ischaemic stroke and timely administration of clot-dissolving therapies,” Professor Anderson added. “In the interim, swift diagnosis and prompt action upon arrival at the emergency department remain critical to preserving brain function during acute stroke management.”

More information: Gang Li et al, Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke, New England Journal of Medicine. DOI: 10.1056/NEJMoa2314741

Journal information: New England Journal of Medicine Provided by The George Institute for Global Health

Study at the University of Cincinnati Utilises Health Metrics to Forecast Kidney Function Recovery

Researchers at the University of Cincinnati College of Medicine have pioneered a groundbreaking predictive model. Using key health indicators, this model forecasts a recovery in patients experiencing kidney failure due to acute kidney injury (AKI). AKI, a significant contributor to end-stage kidney disease (ESKD), ranges from mild kidney function loss to complete failure. Approximately one-third of AKI patients recover kidney function.

Published in the Clinical Kidney Journal, the study analysed health outcomes from 22,922 patients in the U.S. Renal Data System (2005-2014) to predict kidney recovery within 90 days and 12 months after dialysis initiation for AKI-related kidney failure. Lead author Dr Silvi Shah, from UC’s Division of Nephrology, highlighted that patient factors like age, race, body mass index, and medical history (including conditions like heart failure, cancer, and functional status) were crucial in developing their logistic regression model.

Dr. Shah noted that certain factors, such as a history of heart failure, lower body mass index, amputation, and poor functional status, significantly correlated with lower chances of kidney recovery. The study found that 24% and 34% of patients recovered kidney function within 90 days and 12 months, respectively.

The scoring model, a practical tool, aims to assist clinical staff in dialysis units. It quickly assesses patient recovery prospects based on readily available medical history data. According to Dr Charuhas Thakar, a senior author and former division chief of nephrology at the University of Cincinnati, the model categorises patients into high, medium, or low recovery likelihood categories. This categorisation guides personalised treatment plans and resource allocation, empowering healthcare providers with a more targeted approach.

Dr. Thakar emphasised the model’s potential to significantly improve care for AKI patients. It ensures those likely to recover receive focused monitoring while enabling long-term planning, including transplantation, for those less likely to regain kidney function. This potential for improved patient outcomes is a beacon of hope in the field of nephrology.

Dr. Shah underscored the model’s role in risk prediction and patient counselling, noting that individuals with higher scores had a 57% chance of kidney recovery within 90 days. The study, leveraging the extensive U.S. Renal Data System dataset, provided inclusive insights across demographics, enhancing its applicability and individualised patient care strategies.

The research enhances clinical decision-making in dialysis settings, offering healthcare providers and patients valuable insights into recovery expectations and tailored treatment approaches based on predictive risk scores.

More information: Silvi Shah et al, A clinical score to predict recovery in end-stage kidney disease due to acute kidney injury, Clinical Kidney Journal. DOI: 10.1093/ckj/sfae085

Journal information: Clinical Kidney Journal Provided by University of Cincinnati

Treatment Responsiveness and Prolonged Survival in Older Adults with Aggressive Blood Cancer

A study published in Blood Neoplasia indicates that standard treatment for acute myeloid leukemia (AML) in adults over 80 is safe and effective, offering potential for extended survival. Approximately 25% of patients experienced prolonged survival, a significant finding given the aggressive nature of AML. The treatment protocol, known as VEN-HMA (venetoclax combined with a hypomethylating agent), is standard for older adults with AML who cannot undergo intensive chemotherapy due to its immunosuppressive effects and associated risks. This demographic, often at advanced ages, may otherwise be directed towards palliative care.

Dr. Justin Watts, a hematologist at the University of Miami Sylvester Comprehensive Cancer Center, underscores the study’s implications. He highlights that despite challenges, many elderly AML patients benefit from VEN-HMA, challenging assumptions about treatment eligibility based on age alone. The research, spanning data from 154 patients aged 80 to 92 across US and Italian medical institutions, focused on survival rates and treatment responses among octogenarians and nonagenarians receiving VEN-HMA.

Initial findings revealed that 67% of patients started treatment with the standard VEN-HMA regimen, while subsequent adjustments were common, underscoring the need for personalised dosing. Despite concerns about myelosuppression, where bone marrow activity declines, impacting blood cell production and immune function, the study highlighted varied responses and survival outcomes. For those responding to treatment, median survival extended beyond eight months, with some achieving over a year.

Treatment responses varied based on genetic markers, with mutations in TP53 associated with poorer outcomes and those in NPM1 showing favourable survival trends. The study also emphasised the importance of adjusting VEN-HMA dosages to minimise adverse effects while maintaining therapeutic benefits, which is crucial in older patients susceptible to treatment-related complications.

Challenges remain, including the study’s retrospective nature and the need for more extended follow-up periods to validate findings comprehensively. Researchers aim to refine treatment protocols, exploring optimal dosing and scheduling to improve outcomes and quality of life for elderly AML patients. Future investigations will delve into factors like minimal residual disease and molecular subtypes to effectively tailor treatment strategies.

This study underscores evolving paradigms in AML management, advocating for nuanced approaches that consider age-related vulnerabilities and treatment efficacy. It encourages healthcare providers to explore comprehensive treatment options for elderly patients, refraining from restrictive assumptions that might limit therapeutic opportunities.

More information: Ellen Madarang et al, Venetoclax and hypomethylating agents in octogenarians and nonagenarians with acute myeloid leukemia, Blood Neoplasia. DOI: 10.1016/j.bneo.2024.100016

Journal information: Blood Neoplasia Provided by American Society of Hematology

Recommendation on interventions for preventing falls in older adults residing in the community

The U.S. Preventive Services Task Force (USPSTF) strongly advocates exercise interventions as a primary measure to prevent falls among community-dwelling adults aged 65 years and older with an elevated risk of falling. Additionally, the USPSTF suggests that clinicians tailor the decision to provide multifactorial interventions for fall prevention to this same demographic group. The recommendation underscores the importance of considering individual circumstances, including the frequency of prior falls, the presence of concurrent medical conditions, and the patient’s values and preferences when evaluating the appropriateness of such interventions.

Existing evidence highlights that while multifactorial interventions for fall prevention offer some benefits, the overall net benefit remains modest. Therefore, patients, as active participants in their healthcare, and healthcare providers should carefully weigh the potential advantages and drawbacks before opting for these interventions. Factors such as the severity and frequency of previous falls, chronic health conditions, and the patient’s unique preferences should guide decisions about implementing multifactorial fall prevention strategies.

Falls represent a significant public health concern among older adults in the United States, contributing significantly to injury-related morbidity and mortality. Given this impact, the USPSTF continuously evaluates and updates its recommendations regarding the effectiveness of preventive healthcare services. This latest recommendation, replacing the 2018 guideline, reflects the Task Force’s ongoing commitment to enhancing the quality of preventive care for older adults at risk of falls.

More information: Wanda K. Nicholson et al, Interventions to Prevent Falls in Community-Dwelling Older Adults, JAMA. DOI: 10.1001/jama.2024.8481

Journal information: JAMA Provided by JAMA Network

Reconsidering the Care of Patients Admitted for Social Reasons

The categorisation of vulnerable hospital patients as “socially admitted” has been identified as potentially obstructing their medical treatment, as indicated by recent research published in the Canadian Medical Association Journal (CMAJ). Emergency departments often serve as a last resort for socially vulnerable individuals who, despite not presenting with acute or newly arising medical conditions, demonstrate remarkable resilience in seeking care due to a breakdown in support systems or the inability of themselves or their families to manage home-based living conditions. Such individuals are colloquially referred to as “social admissions,” and various labels such as “orphan patient” or “failure to cope” have been applied to them.

Dr. Jasmine Mah, an internal medicine resident focusing on geriatrics at Dalhousie University in Halifax, Nova Scotia, and co-authors highlight that “social admission” remains an under-researched area within healthcare. These patients, often perceived by healthcare providers as not acutely ill, face significantly higher in-hospital mortality rates ranging from 22.2% to 34.9%. Contributing factors may include under-triaging in emergency departments due to inadequate recognition of atypical clinical presentations and delays in timely assessments.

Moreover, there is a risk of misdiagnosis or the development of acute illnesses during hospitalisation. Researchers conducted a qualitative study exploring healthcare providers’ perspectives on “social admissions” in Nova Scotia to gain deeper insights into this patient category. They identified nine overarching themes, including stigma, prejudices such as ageism, wait lists, and other factors influencing perceptions and approaches towards caring for these patients.

The authors emphasise the detrimental impact of labelling patients as “socially admitted” or “orphan patients” (as described in the study hospital), citing instances where such labels lead to incorrect assumptions about medical needs and cognitive abilities. This, in turn, hinders efforts to identify and treat underlying medical issues promptly.

The study reveals that such labelling adversely affects patient health and undermines healthcare providers’ morale. Many providers express conflicted feelings about delivering care to these patients, often feeling that others should handle such care. This attitude risks relegating the care of “socially admitted” patients to team members who may lack sufficient experience in recognising evolving medical conditions or advocating effectively for clinical reassessments when necessary. This hierarchical approach underscores a detachment from the specific needs of this patient demographic.

In response to these findings, the authors passionately advocate for structural reforms within healthcare systems to enhance care delivery for vulnerable populations. They call for a reconsideration of current organisational structures and hierarchies, aiming to eliminate barriers that impede optimal care for socially vulnerable individuals. By doing so, they believe that we can create a healthcare system that is more inclusive, compassionate, and effective in meeting the needs of all patients.

In a related editorial published in CMAJ, Dr Catherine Varner, a deputy editor and emergency medicine physician, along with co-authors Dr Andrew Boozary, a primary care physician, and Dr Andreas Laupacis, editor of CMAJ, argue for a reframing of the issue as a policy failure rather than a personal one. They criticise policies such as Ontario’s alternate level of care policies, which penalise hospitals and patients for occupying beds despite no longer requiring acute care. Such punitive measures, they argue, not only cause distress among patients, families, and providers but also fail to address the root causes of hospital overcrowding.

Instead, they propose embedding collaborative and supportive programmes within healthcare settings, such as multidisciplinary geriatric teams in emergency departments and health teams dedicated to supporting vulnerable populations. These initiatives aim to enhance the management of frail older patients and provide comprehensive support to socially vulnerable individuals, restoring dignity and improving outcomes in healthcare delivery.

Ultimately, the authors stress the paramount importance of addressing structural factors contributing to health disparities as systemic failures rather than individual shortcomings. They call for a paradigm shift towards policies that not only address the complex needs of vulnerable patient populations but also uphold and restore human dignity. This, they argue, is the key to alleviating moral distress among healthcare providers and improving overall healthcare outcomes.

More information: Jasmine C. Mah et al, Managing “socially admitted” patients in hospital: a qualitative study of health care providers’ perceptions, Canadian Medical Association Journal. DOI: 10.1503/cmaj.231430

Journal information: Canadian Medical Association Journal

Implementing Mindfulness Practices in the Workplace to Mitigate Stress and Burnout

A groundbreaking study by researchers at the University of Nottingham’s Schools of Psychology and Medicine has revealed compelling evidence of the relationship between mindfulness and well-being in the digital workplace. The study, based on responses from 142 employees, found that those who practice mindfulness in their digital work environments experience a significant reduction in stress, anxiety, and overload. Published in PLOS ONE, these findings underscore the crucial role of mindfulness in managing the challenges of modern work settings.

Leading the research from the School of Psychology, PhD student Elizabeth Marsh spearheaded a study that aimed to understand the impact of digital technology on individuals’ health and propose effective strategies. Marsh’s insights, “As digital technology increasingly shapes our work, our study aimed to understand its health implications and identify strategies. Our results underscore the need for integrating digital mindfulness and confidence into a healthy digital work-life balance in the 21st century.” This underscores the importance of promoting mindfulness practices in organisations to support employee well-being in the face of digital advancements.

Survey respondents shared perspectives on the challenges posed by the digital workplace, including stress, overload, anxiety, fear of missing out, and addiction, and how these factors influence their health. The study revealed that employees with higher digital confidence exhibited lower susceptibility to digital workplace anxiety. Moreover, those demonstrating elevated levels of mindfulness showed greater resilience against these adversities. Insights from 14 interviews further highlighted how cultivating digital mindfulness can safeguard well-being, presenting a promising avenue for intervention.

Dr. Alexa Spence, Associate Professor of Psychology, highlighted the role of digital workplace technologies in exacerbating employees’ stress perceptions. “Technologies like e-mail, instant messaging, and mobile devices contribute significantly to employees’ stress perceptions,” she observed. “The rapid evolution of the digital workplace can heighten stress levels and potentially lead to burnout and deteriorating health.” This underscores the urgency for organisations to confront digital technology challenges and implement strategies to mitigate their impact on employee well-being.

Mindfulness, defined as intentional and non-judgmental present-moment awareness, emerges as a critical factor in alleviating the negative effects of the digital workplace. Employees with higher mindfulness levels demonstrate reduced vulnerability to the adverse impacts of digital work environments. Professor Elvira Perez Vallejos, a leading authority in Digital Technology for Mental Health, reiterated the implications of the research, stating, “Organisations must actively address digital workplace hazards alongside other psychosocial and physical risks. Fostering mindful awareness among employees engaged in digital work has immense potential to enhance overall well-being.” This underscores the transformative potential of mindfulness interventions in bolstering employee resilience and well-being in the digital era, offering a beacon of optimism for the future.

More information: Elizabeth Marsh et al, Mindfully and confidently digital: A mixed methods study on personal resources to mitigate the dark side of digital working, PLoS ONE. DOI: 10.1371/journal.pone.0295631

Journal information: PLoS ONE Provided by University of Nottingham

Study Reveals Accelerated Ageing of Specific Brain Cells Linked to Alzheimer’s Disease

University of California San Diego engineers have uncovered significant insights into brain cell aging and its implications for Alzheimer’s disease. Their research, published in Nature, utilised the revolutionary MUSIC (multinucleic acid interaction mapping in single cells) technique. This groundbreaking approach delved into the molecular complexities within individual brain cells, offering unprecedented insights into how these dynamics change as brain cells age.

The study, spearheaded by Professor Sheng Zhong from the UC San Diego Jacobs School of Engineering, highlighted a striking finding: specific brain cells exhibit accelerated ageing processes, particularly in individuals affected by Alzheimer’s disease. Notably, the research unveiled sex-specific disparities in ageing patterns, with the female cortex demonstrating a higher prevalence of “old” oligodendrocytes compared to “old” neurons, contrasting with observations in the male cortex.

MUSIC proved instrumental in these discoveries by enabling researchers to analyse postmortem brain samples, specifically from human frontal cortex tissues. Samples were sourced from 14 donors aged 59 years and older, encompassing Alzheimer’s-afflicted individuals and healthy counterparts. This meticulous analysis revealed distinct patterns of chromatin-RNA interactions across various brain cell types. Remarkably, cells exhibiting fewer short-range chromatin interactions tended to show signs of ageing and Alzheimer’s disease pathology.

“This transformative single-cell technology allowed us to identify discrepancies in cellular ageing,” remarked Professor Zhong, underscoring how Alzheimer’s patients displayed more of these aged brain cells than healthy controls.

The implications of this research are profound, suggesting potential avenues for targeted therapeutic interventions. By identifying dysregulated genes within these aged cells and elucidating their roles in local chromatin structures, researchers hope to pinpoint novel therapeutic targets. Xingzhao Wen, a bioinformatics Ph.D. candidate involved in the study, underscored the potential of these findings: understanding the functions of these dysregulated genes could pave the way for innovative treatments aimed at mitigating brain aging and combating neurodegenerative diseases.

Moreover, the study illuminated gender-specific nuances in brain cell ageing dynamics. In female mice, the cortex exhibited a disproportionately higher ratio of aged oligodendrocytes relative to aged neurons. Oligodendrocytes play a crucial role in neuronal insulation and function maintenance; thus, their increased prevalence in an aged state could potentially exacerbate cognitive decline and contribute to heightened susceptibility to neurodegenerative disorders among women. This finding underscores the urgency of addressing gender disparities in neurodegenerative diseases.

“This finding sheds new light on the elevated risks of neurodegenerative conditions observed in women,” noted Wen, highlighting the need for further research to elucidate the underlying mechanisms driving these sex-specific disparities.

Looking ahead, the team aims to refine the MUSIC technique further to identify specific regulatory genes and gene circuits responsible for accelerated ageing in distinct brain cell populations. By understanding these mechanisms in greater detail, they hope to devise strategies to mitigate brain ageing and develop targeted therapies for Alzheimer’s disease and related conditions.

The implications of this research are profound, offering a new paradigm for understanding brain ageing and neurodegenerative diseases. By harnessing the power of MUSIC and similar cutting-edge technologies, scientists are poised to unlock unprecedented insights into the molecular underpinnings of Alzheimer’s disease, potentially transforming how we diagnose, treat, and ultimately prevent cognitive decline associated with ageing. Professor Zhong aptly summarised, “This technology has the potential to revolutionise our understanding of Alzheimer’s pathology and pave the way for personalised therapeutic strategies aimed at improving patient outcomes.”

More information: Xingzhao Wen et al, Single-cell multiplex chromatin and RNA interactions in ageing human brain, Nature. DOI: 10.1038/s41586-024-07239-w

Journal information: Nature Provided by University of California San Diego

Enhanced Walking Ability in Peripheral Artery Disease Patients with Over-the-Counter Supplement

The over-the-counter supplement nicotinamide riboside, a type of vitamin B3, demonstrated significant improvement in walking endurance for patients with peripheral artery disease (PAD), a chronic condition of the legs with limited effective treatments. A preliminary, randomised, double-blind clinical trial by scientists from Northwestern University and the University of Florida revealed that participants who took nicotinamide riboside daily for six months increased their timed walking distance by more than 57 feet compared to those on a placebo. In contrast, participants on the placebo experienced a decline in walking speed, consistent with the progressive nature of PAD affecting walking performance.

“This study suggests nicotinamide riboside could be beneficial for these patients,” noted Christiaan Leeuwenburgh, PhD, a senior author of the trial report and a professor at the University of Florida specialising in physiology and ageing. The collaboration with Mary M. McDermott, M.D., a professor at Northwestern University and an expert in PAD, involved a comprehensive team effort, and their findings were published in the journal Nature Communications on June 13.

Ninety participants, with an average age of 71 and diagnosed with PAD, were recruited for the study to evaluate the effects of nicotinamide riboside. While the supplement has gained popularity in anti-ageing treatments, with U.S. sales exceeding $60 million in 2022, its benefits have been poorly supported by evidence in healthy individuals. Nicotinamide riboside is a precursor to NAD, an essential compound in energy production, enhanced blood flow, and DNA repair processes within the body.

Given that PAD hampers energy generation in muscle cells, McDermott and Leeuwenburgh hypothesised that nicotinamide riboside’s capacity to boost energy production could alleviate walking difficulties associated with the disease. The results supported their hypothesis, demonstrating that participants who adhered to the supplement regimen saw an average increase of 23 feet in their six-minute walking test over six months, while those on placebo experienced a decline of 34 feet. Participants who consistently took at least 75% of the prescribed nicotinamide riboside pills achieved even more significant improvements, adding over 100 feet to their walking distance compared to placebo recipients.

PAD affects more than 8.5 million Americans aged 40 and older, primarily due to arterial fatty deposits compounded by conditions like diabetes and smoking, leading to reduced blood flow to the legs and resultant pain during walking. While supervised walking exercise is the primary therapy for PAD, access to such programmes remains limited for most patients.

Looking ahead, Leeuwenburgh aims to expand their research with more extensive trials focused on PAD patients and to investigate nicotinamide riboside’s impact on walking performance in healthy older adults. “Before recommending nicotinamide riboside for healthy individuals, we must first test its effects in this population,” he emphasised, highlighting the need for further exploration into its broader potential benefits beyond disease-specific contexts.

More information: Mary M. McDermott et al, Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial, Nature Communications. DOI: 10.1038/s41467-024-49092-5

Journal information: Nature Communications Provided by University of Florida

AI-Powered Portable Thermal Imaging for Breast Cancer Pre-Screening

Breast cancer poses significant global health challenges for women, with increasing incidence and mortality rates. Access to mammography screening and diagnosis remains limited, particularly in low- and middle-income countries. This retrospective study evaluated a breast cancer pre-screening solution (BCPS) using a commercially available smartphone with a thermal imaging sensor powered by artificial intelligence. The study aimed to assess the BCPS tool’s performance compared to mammography, the established gold standard for initial breast cancer screening.

Conducted at the Erebouni Medical Center Breast Unit in Armenia over six months, the evaluation involved 478 women, 45 of whom were diagnosed with breast cancer post-biopsy. Participants underwent screening with the BCPS before standard breast screening. Mammography results confirmed malignancy, serving as ground truth for comparison with BCPS AI results.

When combined with patient-reported or clinical symptoms, the BCPS tool achieved 89% sensitivity and 83% specificity compared to mammography. Without clinical or patient-reported symptoms, sensitivity decreased to 60%, while specificity increased to 88.2%.

This study demonstrates that the BCPS tool, leveraging a smartphone-based thermal imaging sensor and AI, aids early breast cancer detection, particularly where mammography is inaccessible. This is not just a technological advancement, but a beacon of hope for low- and middle-income countries, offering a pre-screening option for women who avoid mammography due to various reasons. Further research is warranted to validate these findings and explore additional applications, such as detecting pathological lymph nodes and comparing BCPS with other screening modalities like POCT, MRI, and CEM.

More information: Nerses Berberian et al, Evaluation of an AI-powered Portable Thermal Imaging Solution as a Pre-screening Tool for Breast Cancer, Cancer Screening and Prevention. DOI: 10.14218/CSP.2023.00034S

Journal information: Cancer Screening and Prevention Provided by Xia & He Publishing Inc.