Author Archives: support

Reduced Snoring Risk Associated with Healthy Plant-Based Diet

A study published in ERJ Open Research reveals that individuals who adhere to a healthy, plant-based diet rich in vegetables, fruits, whole grains, and nuts are less likely to experience obstructive sleep apnoea (OSA). Conversely, those consuming an unhealthy plant-based diet, characterised by refined carbohydrates, sugary drinks, and high-salt foods, face an increased risk of OSA.

OSA is marked by loud snoring, interrupted breathing during sleep, and frequent awakenings, leading to daytime fatigue and heightened risks of conditions such as hypertension, stroke, cardiovascular disease, and type 2 diabetes.

Led by Dr Yohannes Melaku from Flinders University, Australia, the study analysed data from 14,210 participants in the US National Health and Nutrition Examination Survey. Participants reported their dietary intake over 24 hours, which researchers categorised into healthy and unhealthy plant-based diets and diets high in animal products. They also completed questionnaires assessing OSA symptoms.

Results indicated that those consuming diets rich in plant-based foods were 19% less likely to suffer from OSA than those with the lowest plant-based food intake. Conversely, individuals consuming high amounts of unhealthy plant-based foods faced a 22% higher risk of OSA.

Interestingly, the study found varying impacts on OSA risk based on gender, with men showing a stronger correlation between a plant-based diet and reduced OSA risk than women. This highlights the potential for personalised dietary interventions in managing OSA.

Dr Melaku emphasised that the study underscores the role of diet quality in OSA management, suggesting that the anti-inflammatory and antioxidant properties of a healthy plant-based diet may mitigate factors like inflammation and obesity that contribute to OSA risk.

Moving forward, researchers plan to investigate the relationship between ultra-processed foods and OSA risk in the same cohort, as well as explore long-term interactions between diet and OSA risk.

Commenting on the study, Professor Sophia Schiza from the University of Crete, Greece, noted the prevalence of undiagnosed OSA and stressed the importance of dietary modifications alongside other lifestyle changes like smoking cessation, weight management, and physical activity.

The study highlights the potential benefits of adopting a diet rich in vegetables, fruits, and whole grains while minimising intake of unhealthy foods and sugary drinks to manage or prevent OSA. It calls for broader public awareness and support for healthier dietary choices to improve overall health outcomes related to sleep disorders like OSA.

More information: Yohannes Adama Melaku et al, Plant-based and vegetarian diets are associated with reduced obstructive sleep apnoea risk, ERJ Open Research. DOI: 10.1183/23120541.00739-2023

Journal information: ERJ Open Research Provided by European Respiratory Society

Blood test predicts Parkinson’s disease onset seven years before symptoms

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A team led by researchers from UCL and University Medical Center Goettingen has developed a straightforward blood test employing artificial intelligence (AI) to predict Parkinson’s disease up to seven years before symptoms manifest. Parkinson’s disease stands as the fastest-growing neurodegenerative disorder worldwide, affecting nearly 10 million people. This progressive condition results from the degeneration of nerve cells in the substantia nigra region of the brain, responsible for movement control. The loss of these cells impairs dopamine production, driven by the accumulation of alpha-synuclein protein.

Currently, treatment involves dopamine replacement therapy administered after symptoms like tremors, slowed movement, and cognitive issues appear. Early detection holds promise for initiating treatments that could protect dopamine-producing brain cells, potentially slowing or halting disease progression. Professor Kevin Mills, senior author from UCL Great Ormond Street Institute of Child Health, emphasised the importance of diagnosing Parkinson’s before symptom onset to safeguard existing brain cells. The team utilised cutting-edge technology to identify new biomarkers for the disease and developed a test intended for integration into large NHS laboratories within two years, given adequate funding.

Published in Nature Communications, their research demonstrated that a panel of eight blood-based biomarkers, analysed using machine learning, achieved 100% diagnostic accuracy for Parkinson’s. Testing involved 72 patients with Rapid Eye Movement Behaviour Disorder (iRBD), a precursor to synucleinopathies, including Parkinson’s. The AI successfully identified 79% of iRBD patients sharing biomarker profiles with Parkinson’s patients. Over a decade-long follow-up, the AI predictions correlated with clinical outcomes, accurately forecasting Parkinson’s onset up to seven years in advance for 16 patients initially diagnosed with iRBD.

Dr Michael Bartl, co-first author from University Medical Center Goettingen, highlighted the potential of identifying Parkinson’s patients years before symptoms emerge, enabling earlier intervention with potential disease-modifying therapies. The identified biomarkers, linked to inflammation and protein degradation processes, present new avenues for drug development. Co-author Professor Kailash Bhatia, from UCL Queen Square Institute of Neurology, and his team are assessing the test’s precision using samples from high-risk populations, such as individuals with genetic mutations predisposing them to Parkinson’s.

Future efforts aim to simplify the test into a blood spot format, facilitating more accessible sample collection and mail-in testing. Funding from EU Horizon 2020, Parkinson’s UK, NIHR GOSH Biomedical Research Centre, and the Szeben-Peto Foundation supported this groundbreaking research. Professor David Dexter, Director of Research at Parkinson’s UK, hailed the study’s potential to revolutionise Parkinson’s diagnosis with a non-invasive blood test, contrasting it favourably with more invasive lumbar punctures used in current research. Hopefully, this blood-based approach could distinguish Parkinson’s from similar conditions early on, enhancing diagnostic precision and paving the way for timely interventions.

The development of this AI-driven blood test represents a significant advancement in Parkinson’s research, promising earlier diagnosis and potentially transformative treatments. The ongoing validation and future refinements hold promise for widespread clinical application, offering hope to millions affected by this challenging neurodegenerative disease.

More information: Jenny Hällqvist et al, Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset, Nature Communications. DOI: 10.1038/s41467-024-48961-3

Journal information: Nature Communications Provided by University College London

Strategies to Tackle Homelessness Among Older Adults

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Homelessness affects not only young people but also a growing number of older adults, as highlighted in an analysis in CMAJ (Canadian Medical Association Journal). Visible signs of ageing are often evident at younger ages among individuals experiencing homelessness compared to those with stable housing. This population frequently suffers from earlier onset of chronic medical conditions and age-related issues like cognitive impairment.

The risk of premature death among older homeless individuals is notably higher—3.5 times greater than their housed counterparts, particularly for those experiencing homelessness for the first time later in life. In 2021, 32% of individuals in Canadian shelters were aged 50 and older, with many others living outdoors or temporarily with friends or family.

Dr. Jillian Alston, a geriatrician at St. Michael’s Hospital, Unity Health Toronto, and her coauthors stress the need for shelter policies and government strategies tailored to the care needs of older adults experiencing homelessness. They advocate for age-friendly shelters with appropriate physical environments, adequate staffing, and access to essential medical services. These individuals often face substantial marginalization, dehumanization, and structural violence, necessitating care models focused on building trust, establishing rapport, and ensuring personal safety.

It is crucial to provide housing that meets individual needs to support older adults at risk or experiencing homelessness. Conditions like cognitive impairment and mobility issues, common with ageing, can challenge housing stability. Preventive measures include tenancy monitoring programs, personalized in-home supports, and community initiatives addressing social isolation. Health care programs within shelters, such as primary care and geriatric outreach services, play a vital role in supporting older adults.

Innovative housing solutions, such as The Oaks in Ottawa, demonstrate effective models for permanent supportive housing that accommodate ageing. Long-term care homes may provide the most suitable environment for some individuals to address their complex needs.

Addressing this pressing issue requires collaborative efforts across health care, long-term care, public health, housing sectors, and community support. Trauma-informed approaches are essential for individuals who have experienced adversity and trauma earlier in their lives.

Dr Andrew Boozary, Dr Catherine Varner, and Dr Andreas Laupacis emphasize the profound human toll of homelessness in their editorial. Chronically unhoused individuals have significantly shorter lifespans, experience accelerated ageing, and develop multiple health conditions at younger ages compared to their housed counterparts. Homelessness disproportionately affects Indigenous, Black, refugee, newcomer, and 2SLGBTQ+ communities.

To combat this crisis, some health networks are pioneering initiatives to build affordable housing for unhoused individuals, underscoring the urgency and scale of the homelessness problem. Hospitals redirect resources towards housing initiatives, highlighting the inadequacies and high costs associated with conventional approaches such as lengthy hospital admissions.

Urgent action is needed to address the marginalization and health disparities faced by older adults experiencing homelessness. Comprehensive strategies must encompass housing stability, tailored healthcare interventions, and community support systems to ensure dignified and sustainable solutions for this vulnerable population.

More information: Jillian Alston et al, Tackling late-life homelessness in Canada, Canadian Medical Association Journal. DOI: 10.1503/cmaj.231493

Journal information: Canadian Medical Association Journal

Enhancing Weight Loss Outcomes in Primary Care Clinics Through Obesity Specialist Integration

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In a recent University of Michigan study published in JAMA Network Open, researchers found that integrating obesity specialists into primary care clinics significantly enhanced weight loss outcomes for high-risk patients. The study focused on patients who had access to the collaborative Weight Navigation Program (WNP), designed to provide individualized obesity treatment plans through a team effort between patients, primary care providers, and board-certified obesity specialists.

Traditionally, primary care clinicians struggle to develop comprehensive weight-management plans during short clinic visits. Previous research highlighted that many patients with obesity fail to achieve the recommended 5% reduction in body weight, which can mitigate obesity-related health risks. Recognising this gap, Michigan Medicine launched the WNP in 2020, aiming to bridge this divide by integrating specialist expertise within routine primary care settings.

The study’s findings were compelling: over a year, participants in the WNP experienced an average weight loss of approximately 12 pounds, equivalent to about 4.4% of their initial body weight. In contrast, patients receiving standard care at similar clinics without the WNP showed minimal weight loss. More than 40% of WNP participants achieved the 5% weight loss goal, compared to less than 20% of their counterparts in standard care. Additionally, 22% of WNP patients achieved at least a 10% reduction in body weight, significantly higher than the less than 4% in the comparison group.

The success of the WNP underscores its potential as a scalable model for improving obesity care in primary care settings, offering a beacon of hope for the future. The programme is now accessible to eligible adult patients across U-M Health clinics, offering a gateway to various specialised weight management interventions. Dr. Dina Hafez Griauzde, the study’s lead author, emphasised the WNP’s collaborative approach, where obesity specialists work alongside primary care providers to tailor treatment plans that consider medical conditions, financial constraints, and patient preferences.

Moreover, the study highlighted disparities in referral rates for advanced obesity treatments between WNP participants and those in standard care. WNP patients were twice as likely to be referred for evaluations for bariatric surgery, reflecting a proactive approach to comprehensive obesity management within primary care. They were more frequently directed to specialised weight loss programmes, such as those focusing on low-calorie meal replacements or Mediterranean-style diets. Additionally, a notable proportion of WNP patients received prescriptions for obesity medications, further reinforcing the effectiveness of the program.

However, the study’s scope predates recent advancements in obesity pharmacotherapy, such as semaglutide and tirzepatide, approved by the FDA for weight management. Future research must evaluate how these newer treatments influence weight loss outcomes within integrated care models like the WNP. The findings underscore the potential of collaborative obesity care models to address the growing obesity epidemic by leveraging existing primary care infrastructure and specialist expertise effectively.

The University of Michigan’s Weight Navigation Program represents a promising paradigm for enhancing obesity management in primary care. By integrating obesity specialists into routine clinical practice, the programme facilitated weight loss and improved access to specialised treatments. Expanding such integrated care models could play a crucial role in improving health outcomes for individuals struggling with obesity-related conditions.

More information: Dina H. Griauzde et al, A Primary Care–Based Weight Navigation Program, JAMA Network Open. DOI: 10.1001/jamanetworkopen.2024.12192

Journal information: JAMA Network Open Provided by Michigan Medicine – University of Michigan

Vitamin B12’s role in cellular reprogramming and tissue regeneration

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Vitamin B12 is a well-known micronutrient vital for nerve function, red blood cell production, and DNA synthesis. Recently, Dr. Manuel Serrano and his team at IRB Barcelona have highlighted its additional role in cellular reprogramming and tissue regeneration, as reported in Nature Metabolism.

Their research focused on cellular reprogramming, mimicking early tissue repair stages. They discovered that this process in mice requires substantial amounts of vitamin B12. Surprisingly, even with B12 naturally abundant in mouse diets, its supplementation significantly boosted reprogramming efficiency, indicating its critical role.

The study also explored ulcerative colitis, finding similarities between repair-initiating intestinal cells and reprogramming processes, benefiting from vitamin B12 supplementation. This suggests potential therapeutic benefits for patients with intestinal bowel diseases through improved nutrition.

Dr. Manuel Serrano underscores the findings’ significance for regenerative medicine, emphasizing vitamin B12’s role in enhancing cellular reprogramming and tissue repair.

The researchers delved into cellular reprogramming’s metabolic demands, identifying vitamin B12 as crucial for methylation reactions vital in DNA function during reprogramming and repair. Insufficient B12 led to significant epigenetic changes, impacting gene function. Supplementation corrected this, enhancing gene fidelity and reprogramming efficiency.

Dr Marta Kovatcheva, the study’s lead author and future head of a Milan-based laboratory at IFOM, highlights vitamin B12’s corrective role in maintaining gene function fidelity during reprogramming.

In collaboration with Dr Rosa Lamuela-Raventós and Dr Ramon Estruch, a separate study by Dr Serrano’s team explored vitamin B12’s anti-inflammatory potential. Higher blood B12 levels correlated with lower inflammatory markers in humans and aged mice, suggesting B12’s role in reducing inflammation and its potential health benefits.

These findings underscore vitamin B12’s multifaceted role—from cellular reprogramming facilitation to anti-inflammatory action—promising advancements in regenerative medicine and potential therapeutic strategies for inflammatory conditions.

More information: Marta Kovatcheva et al, Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair, Nature Metabolism. DOI: 10.1038/s42255-023-00916-6

Journal information: Nature Metabolism Provided by IRB Barcelona – Institute for Research in Biomedicine

Rapid Impact on Immune System: Transitioning to Vegan or Ketogenic Diets

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Researchers at the National Institutes of Health have identified rapid and distinct changes in the immune systems of individuals who transitioned to either a vegan or ketogenic (keto) diet. Conducted at the NIH Clinical Center’s Metabolic Clinical Research Unit, the study closely monitored biological responses in participants as they sequentially adopted vegan and keto diets for two-week periods. The findings revealed that the vegan diet stimulated responses associated with innate immunity—our body’s initial non-specific defence against pathogens—while the keto diet triggered responses linked to adaptive immunity, which develops specificity through exposure and vaccination.

In addition to immune responses, the study observed significant metabolic changes and shifts in the participants’ gut microbiomes, the communities of bacteria residing in the digestive tract. These findings underscore the potential impacts of dietary choices on health outcomes, particularly in conditions such as cancer and inflammatory diseases. However, further research is essential to determine whether these observed changes are beneficial or detrimental in the context of nutritional interventions.

Scientific understanding of how diets influence the human immune system and microbiome remains limited, particularly regarding therapeutic nutritional interventions to improve health outcomes. Comparisons between diets are scarce, with the keto diet characterized by low carbohydrate intake and high fat content. In contrast, the vegan diet excludes animal products and is typically high in fibre and low in fat.

The study, conducted by researchers from the NIH’s National Institute of Allergy and Infectious Diseases (NIAID) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), involved 20 diverse participants in terms of ethnicity, race, gender, body mass index (BMI), and age. Each participant consumed ad libitum quantities of one diet (vegan or keto) for two weeks, followed by another for two weeks in a random order. Throughout the study, comprehensive analyses of blood, urine, and stool samples were conducted to assess biochemical, cellular, metabolic, and immune responses and microbiome changes.

Both diets induced notable changes across all participants. The vegan diet prominently affected pathways associated with innate immunity, particularly antiviral responses. Conversely, the keto diet triggered significant increases in biochemical and cellular processes linked to adaptive immunity, including pathways involving T and B cells. Furthermore, the keto diet influenced a broader range of proteins in the blood plasma and tissues compared to the vegan diet. It also impacted amino acid metabolism differently, reflecting this dietary approach’s higher protein content characteristic.

Beyond immune responses, both diets caused shifts in the participants’ gut microbiomes, altering the abundance of bacterial species associated with each diet type. The vegan diet notably influenced pathways related to red blood cells and heme metabolism, possibly due to its higher iron content. These findings highlight the interconnectedness of diet with metabolic and immune pathways, illustrating how dietary changes can impact multiple physiological systems in a relatively short period.

The study’s findings emphasize the rapid and interconnected nature of the body’s response to dietary interventions. Despite the diversity among participants, consistent and significant changes were observed across various physiological pathways. This underscores the potential for tailored dietary interventions to empower individuals to influence disease prevention and complement existing treatments for conditions such as cancer and neurodegenerative disorders.

In conclusion, while the study provides valuable insights into how vegan and keto diets affect immune responses, metabolism, and microbiomes, it also highlights the ongoing need for further research. Understanding the precise mechanisms underlying dietary impacts on health is a collective endeavour that can pave the way for more targeted nutritional strategies to improve overall well-being and manage chronic diseases effectively.

More information: Verena M. Link et al, Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans, Nature Medicine. DOI: 10.1038/s41591-023-02761-2

Journal information: Nature Medicine Provided by National Institutes of Health / National Institute of Allergy and Infectious Diseases

Chilling ‘blood oranges’ could enhance their health benefits – an added perk for consumers

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Recent research from the University of Florida highlights the potential health benefits of blood oranges, which are rich in anthocyanins and other phytochemicals known for their anti-inflammatory and antioxidant properties. A study led by Ali Sarkhosh, UF/IFAS associate professor of horticultural sciences, and his post-doctoral associate Fariborz Habibi explores how storing blood oranges at cooler temperatures could enhance their nutritional profile and market appeal.

The study suggests maintaining temperatures between 40 to 53 degrees Fahrenheit boosts anthocyanins, phenolic content, and antioxidants in blood oranges. Lowering temperatures to 43 to 46 degrees Fahrenheit preserves fruit firmness, minimises weight loss, and retains sugar content. These findings indicate a potential for improved fruit quality and prolonged shelf life, offering a promising opportunity for the Florida citrus industry.

Despite these benefits, Sarkhosh and Habibi caution that further research is needed to determine the viability of blood oranges as a profitable crop for Florida citrus growers. While blood oranges typically command higher prices than common varieties like navel or Valencia oranges, the study underscores the need to evaluate whether farmers could significantly enhance per-acre income by incorporating them into their crop selection and adopting specialised storage practices.

The Mediterranean climate, conducive to blood orange cultivation, particularly in Italy and Spain, contrasts with Florida’s subtropical conditions. In the United States, blood oranges are primarily grown in California, with limited commercial cultivation in Florida. Anthocyanin development, crucial for the characteristic deep red flesh of blood oranges, requires exposure to specific cold temperatures, typically between 46 and 59 degrees Fahrenheit, for a minimum duration of 20 days – conditions not commonly met in Florida.

While the study offers promising insights into enhancing blood orange quality through controlled storage, its practical application and economic feasibility for Florida growers remain subjects of ongoing investigation. Sarkhosh emphasises that while consumers can encourage internal colour development in fruit stored at home, supermarket offerings should ideally meet quality standards for immediate consumption.

This research underscores the potential health benefits and market advantages of blood oranges, contingent upon further exploration of storage techniques and economic viability within Florida’s citrus industry.

More information: Fariborz Habibi et al, Postharvest storage temperature strategies affect anthocyanin levels, total phenolic content, antioxidant activity, chemical attributes of juice, and physical qualities of blood orange fruit, Food Chemistry Advances. DOI: 10.1016/j.focha.2024.100722

Journal information: Food Chemistry Advances Provided by University of Florida

Revolutionising Cancer Treatment: Harnessing Targeted Nutrients for Therapeutic Success

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An international team of researchers has pioneered a novel approach to combat cancer by leveraging nutrients to reawaken suppressed metabolic pathways within cancer cells. Their breakthrough, which involves using a common amino acid, tyrosine, encapsulated in nanomedicine form to alter the metabolism of melanoma, a particularly aggressive form of skin cancer, thereby inhibiting its growth, holds immense potential for the future of cancer treatment.

Melanoma poses a significant health challenge in countries like Australia, which has the highest incidence of skin cancer globally. This innovative treatment method, potentially augmenting existing therapies, represents a significant advancement in melanoma treatment and holds promise for addressing other types of cancer.

Led by Professor Wenbo Bu from Fudan University and Professor Dayong Jin from the University of Technology Sydney, the study titled “Nutrient-delivery and metabolism reactivation therapy for melanoma” was recently published in Nature Nanotechnology, underscoring its scientific significance. The researchers tackled the challenge of tyrosine’s limited bioavailability in living organisms by employing advanced nanotechnology to encapsulate it into nanomicelles—tiny particles that specifically target cancer cell membranes, enhancing absorption and efficacy.

Experimental validation in mouse models and human-derived melanoma cells demonstrated that tyrosine nanomicelles effectively revived dormant metabolic pathways within cancer cells. This action stimulated melanin synthesis, crucial for melanoma cells derived from melanocytes, and suppressed glycolysis—the process through which cancer cells convert sugars into energy to fuel their rapid proliferation.

Professor Dayong Jin highlighted the distinctive feature of cancer cells—uncontrolled growth driven by altered metabolic pathways. While existing cancer treatments often focus on inhibiting overactive metabolic processes, such as those involving aromatase inhibitors in breast cancer or HK2 inhibitors in various cancers, this study proposes a paradigm shift by reactivating dormant pathways essential for cancer cell survival.

Professor Wenbo Bu emphasised the safety and availability of nutrient-based approaches, contrasting them favourably with more conventional pharmacological interventions. By harnessing simple and widely tolerated nutrients like amino acids, sugars, and vitamins, the researchers believe they have uncovered a fundamentally new strategy to combat cancer, providing a sense of reassurance to the audience.

The specificity of nutrient response varies across different types of cancer. In the case of melanoma, which originates from melanocytes responsible for melanin production, tyrosine plays a pivotal role in melanin synthesis. The reactivation of melanin production induced by tyrosine nanomicelles effectively forces melanoma cells to downregulate glycolysis, thus impairing their ability to sustain rapid growth—a crucial mechanism underpinning the therapeutic efficacy observed in the study.

Moreover, the researchers explored synergistic treatment modalities to enhance therapeutic outcomes. Combining tyrosine nanomicelle therapy with near-infrared laser treatment exploited the susceptibility of melanoma cells to heat stress, resulting in complete eradication of melanoma in experimental mice within a remarkably short period.

The study’s findings collectively underscore the potential of nanomedicine in reshaping cancer therapy paradigms. By ingeniously leveraging nutrient-based nanotechnology to modulate metabolic pathways, this research opens new avenues for personalised cancer treatments that could significantly improve patient outcomes.

Professor Bu, Professor Jin, and their international research team’s pioneering work represents a transformative approach to cancer treatment. Their use of tyrosine nanomicelles to reawaken dormant metabolic pathways in melanoma cells not only inhibits tumour growth but also demonstrates the broader applicability of nutrient-based therapies in combating various types of cancer. This promising advancement not only highlights the power of nanotechnology in medicine but also offers hope for more effective, personalised cancer treatments in the future, inspiring the audience with the potential impact of the work.

More information: Yang Chen et al, Nutrient-delivery and metabolism reactivation therapy for melanoma, Nature Nanotechnology. DOI: 10.1038/s41565-024-01690-6

Journal information: Nature Nanotechnology Provided by University of Technology Sydney

Duke-NUS research highlights prevalent use of physical restraints in home care for elderly individuals with dementia

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A recent study by Duke-NUS Medical School has highlighted the widespread use of physical restraints among caregivers of older adults with advanced dementia living at home. Nearly half (47%) of surveyed caregivers reported using physical restraints on family members with dementia, revealing significant gaps in support and resources. This practice is concerning as it can negatively impact the physical and psychological health of older adults, potentially leading to depression, stress, incontinence, and cognitive decline.

In Singapore, where the elderly population is rapidly growing, with projections suggesting they will make up nearly a quarter of the population by 2030, dementia prevalence is also expected to rise. Despite physical restraints being prohibited mainly in nursing homes in other countries, their use in home settings for dementia care has not been extensively studied until now.

Assistant Professor Chetna Malhotra from Duke-NUS highlighted the unique challenges in caring for older adults with severe dementia, particularly regarding the use of physical restraints. Common restraints reported in the study included belts, locked chairs, hand mittens, and ankle or wrist ties, primarily used for safety reasons such as fall prevention and managing agitation.

The study, involving 215 family caregivers, underscored that emotional support from friends reduced the likelihood of restraint use, whereas caregivers experiencing higher psychological distress or juggling multiple caregiving roles were more inclined to resort to restraints. These findings underline the need for better support systems and alternative care approaches to ensure compassionate and effective dementia care at home.

Dr Ellie Bostwick Andres, the study’s first author, highlighted the pressures caregivers face. They often view restraints as necessary for safety without fully understanding their detrimental effects on the quality of life for those with dementia. The research urges a shift towards supportive care strategies that address the complex needs of older adults with dementia while minimising the use of restrictive practices.

Professor Patrick Tan, Senior Vice-Dean for Research at Duke-NUS, emphasised the study’s implications for Singapore’s ageing population, advocating for policies that promote more compassionate and responsive dementia care approaches at home. This research raises awareness and calls for systemic changes to improve outcomes for older adults and their caregivers in Singapore and beyond.

More information: Ellie Bostwick Andres et al, Caregiver-reported use of physical restraints among community-dwelling older adults with severe dementia in Singapore, Journal of the American Geriatrics Society. DOI: 10.1111/jgs.18797

Journal information: Journal of the American Geriatrics Society Provided by Duke-NUS Medical School

Study discovers the crucial role of biodiversity in promoting mental well-being through nature

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A study from King’s College London has revealed that environments featuring diverse natural elements significantly enhance mental wellbeing compared to those with less natural diversity. Published in Scientific Reports and supported by the National Institute for Health and Care Research (NIHR) and Wellcome, this citizen science investigation utilised the Urban Mind smartphone app to gather real-time reports on mental wellbeing and natural diversity from nearly 2000 participants.

The research identified that settings enriched with various natural features such as trees, birds, plants, and waterways correlate with more significant improvements in mental health. These effects can endure for up to eight hours. The analysis further indicated that approximately one-quarter of nature’s positive impact on mental health could be attributed to diverse natural features. These findings underscore the benefits of policies and practices that foster biodiversity for environmental conservation and public mental health.

Lead author Ryan Hammoud, Research Assistant at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London, underscored the profound significance of the study’s findings:

“This study represents a pioneering effort in examining how encounters with different levels of natural diversity in everyday life contexts influence mental health. Our findings underscore the importance of safeguarding and promoting natural diversity to maximise the mental health benefits of exposure to nature. Practically, this calls for moving away from heavily curated monocultural spaces like manicured lawns and parks towards environments that emulate the biodiversity of natural ecosystems. By demonstrating how natural diversity enhances our mental wellbeing, we provide a compelling rationale for creating greener and healthier urban areas.”

The study was conducted between April 2018 and September 2023 and involved 1,998 participants who completed over 41,000 assessments. Each participant submitted three daily assessments over two weeks, detailing their surroundings and responding to questions regarding their mental health. Natural diversity was quantified based on the presence of four key elements – trees, plants, birds, and water – in their immediate environment.

Data collection was facilitated through the Urban Mind app, a collaborative effort between King’s College London, landscape architects J&L Gibbons, and the arts foundation Nomad Projects. The Urban Mind project, a testament to the power of collaboration, received funding from the Wellcome Climate Impacts Award, the National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, and the NIHR Applied Research Collaboration South London.

Senior author Andrea Mechelli, Professor of Early Intervention in Mental Health at the IoPPN, emphasised the broader implications of the findings: “Amidst the backdrop of climate change, there is an alarming decline in biodiversity both in the UK and globally. Our results underscore the critical role of biodiversity not only in sustaining natural environments but also in promoting the mental wellbeing of those inhabiting these environments. It is imperative to recognise that biodiversity offers mutual benefits for planetary and human health and should be viewed as essential urban infrastructure.”

This study contributes significantly to understanding the intricate relationship between natural diversity and mental health, advocating for policies prioritising biodiversity conservation to foster healthier urban environments.

More information: Ryan Hammoud et al, Smartphone-based ecological momentary assessment reveals an incremental association between natural diversity and mental wellbeing, Scientific Reports. DOI: 10.1038/s41598-024-55940-7

Journal information: Scientific Reports Provided by King’s College London

Study Finds Weight Loss Possible Whether Exercising Regularly or Just One to Two Days a Week

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A new study published in the journal Obesity, the flagship publication of The Obesity Society (TOS), reveals that both regular and occasional physical activity can contribute to weight loss. This study, pioneering in examining physical activity patterns and their impact on fat tissue mass, challenges conventional guidelines that prescribe specific weekly exercise frequencies. According to World Health Organization (WHO) recommendations, adults should ideally engage in at least 150 minutes of moderate physical activity per week, 75 minutes of vigorous activity, or a combination of both. However, meeting these guidelines can be daunting in today’s fast-paced society, where time constraints often hinder consistent exercise routines.

The research, conducted by healthcare scientist Lihua Zhang from Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, focuses on the concept of “weekend warriors” — individuals who concentrate their exercise into one or two sessions per week. This approach was equally effective in promoting weight loss compared to more frequent exercise routines, provided that the recommended activity goals were achieved.

Zhang emphasises the relevance of this finding for individuals who struggle to integrate regular exercise into their daily lives due to sedentary occupations, such as office workers and bus drivers. “Our study offers an alternative option for them to stay fit,” Zhang explains, suggesting outdoor activities like climbing, hiking, cycling, or running as suitable options for weekend warriors.

The study analysed data from over 9,600 participants aged 20 to 59, drawn from the National Health and Nutrition Examination Survey from 2011 to 2018. Using dual-energy X-ray absorptiometry (DXA) and anthropometric measures, researchers assessed abdominal and overall adiposity. Physical activity levels were categorised as inactive, weekend warrior, or regularly active based on the Global Physical Activity Questionnaire. Linear regression models explored associations between physical activity patterns and adiposity indicators.

Results indicated that participants adopting the weekend warrior approach, alongside those who were regularly active, exhibited lower levels of abdominal adiposity, waist circumference, whole-body fat mass, and body mass index than inactive individuals. Furthermore, both the weekend warrior and regularly active groups tended to be younger, more educated, and less likely to have hypertension or diabetes compared to their inactive counterparts.

Dr. Beverly Tchang, Assistant Professor of Clinical Medicine at the Comprehensive Weight Control Center, Weill Cornell Medicine, New York, who was not involved in the study, underscores the broader implications of these findings. “This study reinforces the fundamental principle that any level of physical activity is beneficial for health,” Dr. Tchang explains. She highlights that the intensity and duration of the weekend warriors’ workouts correlated with even more significant reductions in abdominal fat. Still, the key takeaway is choosing physical activities that fit individual lifestyles.

This study challenges traditional notions about the frequency of exercise required for weight loss, suggesting that regular engagement and condensed, intense activity sessions can yield significant health benefits. It provides valuable insights for public health recommendations, particularly for individuals with limited time for exercise due to work or other commitments, offering them a feasible pathway to improve fitness and reduce adiposity through effective physical activity strategies.

More information: Lubi Lei et al, The associations of “weekend warrior” and regularly active physical activity with abdominal and general adiposity in US adults, Obesity. DOI: 10.1002/oby.23986

Journal information: Obesity Provided by The Obesity Society

Exploring the Potential of Cancer Drug for Targeting Protein Links in Parkinson’s Disease

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In a study involving genetically engineered mice, researchers from Johns Hopkins Medicine have identified a potential new target involving Aplp1, a cell surface protein implicated in the propagation of alpha-synuclein, the protein associated with Parkinson’s disease. The findings in Nature Communications on May 31 illustrate how Aplp1 interacts with Lag3, another cell surface receptor, facilitating the spread of harmful alpha-synuclein proteins between brain cells, a hallmark of Parkinson’s disease.

The research underscores Lag3’s role as a target for a combination cancer drug already approved by the FDA, which utilises antibodies to direct the immune system towards eliminating specific targets. According to Xiaobo Mao, Ph.D., associate professor of neurology at Johns Hopkins University School of Medicine and a member of the Institute for Cell Engineering, understanding the Aplp1-Lag3 interaction provides new insights into alpha-synuclein’s role in Parkinson’s disease progression. Mao suggests that targeting this interaction with pharmaceutical interventions could potentially bring hope and optimism by slowing disease advancement in Parkinson’s and other neurodegenerative disorders.

The study, co-led by Mao and Ted Dawson, M.D., PhD, also involved Valina Dawson, PhD, and Hanseok Ko, PhD, all esteemed professors at Johns Hopkins University School of Medicine and researchers at the Institute for Cell Engineering. Previous research has established that misfolded alpha-synuclein proteins aggregate and move from one brain cell to another, causing cell death in dopamine-producing neurons—a process identified by Johns Hopkins researchers as parthanatos, a form of programmed cell death. This process leads to movement impairments, emotional instability, and cognitive decline, characteristic of Parkinson’s disease.

The researchers explain that Aplp1’s interaction with Lag3 on the cell surface facilitates the uptake of alpha-synuclein aggregates by healthy brain cells, ultimately contributing to their demise. Previous studies by Mao and Dawson’s team have highlighted Lag3’s role in binding with alpha-synuclein and promoting disease spread, with recent experiments focusing on Aplp1’s involvement in this process.

Using genetically modified mice lacking Aplp1, Lag3, or both proteins, researchers observed a significant reduction—up to 90%—in the uptake of harmful alpha-synuclein proteins by brain cells. Furthermore, administering the Lag3 antibody blocked the interaction between Aplp1 and Lag3, preventing healthy brain cells from absorbing disease-associated alpha-synuclein aggregates.

Ted Dawson notes that the Lag3 antibody, specifically nivolumab/relatlimab, approved for cancer treatment in 2022, demonstrated efficacy in halting the spread of alpha-synuclein seeds in mouse models. Due to Aplp1’s close association with Lag3, the antibody surpasses the effectiveness of Lag3 depletion alone.

The implications of this research extend beyond Parkinson’s disease, potentially influencing treatment approaches for other neurodegenerative conditions lacking definitive cures. In Alzheimer’s disease, characterised by memory loss, mood disturbances, and muscle problems, tau proteins undergo misfolding and aggregation in neurons, exacerbating the disease. Mao suggests that targeting Lag3, which also interacts with tau proteins implicated in dementia, with the same antibody approach could yield intriguing therapeutic benefits in Alzheimer’s research.

Following the promising outcomes with the Lag3 antibody in mice models, Ted Dawson outlines plans for future trials involving anti-Lag3 antibodies in both Parkinson’s and Alzheimer’s disease models. Additionally, Johns Hopkins researchers are exploring strategies to prevent unhealthy cells from releasing alpha-synuclein, potentially intercepting disease progression at an early stage. These promising outcomes should encourage and inspire the scientific community in future research and trials.

More information: Xiaobo Mao et al, Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein, Nature Communications. DOI: 10.1038/s41467-024-49016-3

Journal information: Nature Communications Provided by Johns Hopkins Medicine