Daily Archives: 10 May 2024

Perceived gender discrimination associated with a decrease in wellbeing among older women

A research project involving over 3,000 middle-aged and later-aged women in England has uncovered that individuals who felt they had been subjected to gender discrimination were more prone to experiencing declines in their wellbeing over time. Ruth Hackett from King’s College London, UK, and her team shared these insights in the open-access journal PLOS ONE on March 20, 2024.

Previous studies have indicated that individuals who believe they have faced gender discrimination tend to report lower mental wellbeing. However, these studies often did not track wellbeing longitudinally or primarily focused on younger demographics.

To understand how this dynamic plays out among older women, Hackett and her colleagues examined data from 3,081 participants in the English Longitudinal Study of Ageing (ELSA), which tracks a broad demographic of people over 50.

During 2010 or 2011, each participant responded to queries regarding the frequency of their encounters with various forms of discrimination, such as harassment or receiving less respect or courtesy, and whether they attributed these experiences to their gender or another characteristic like race or age. They also completed standard questionnaires to assess mental wellbeing on two occasions, first in 2010 or 2011 and then in 2016 or 2017.

About 9.2 per cent of the participants reported experiencing gender discrimination, often in situations where they were treated with less respect or courtesy. Notably, those who perceived gender discrimination reported higher instances of depressive symptoms, increased loneliness, and a decline in both quality of life and life satisfaction. From one time point to the next, there was a tendency among these women to report worsened quality of life and life satisfaction, along with heightened feelings of loneliness. These observations remained significant even after adjusting for other factors related to wellbeing, such as age, wealth, and physical activity levels.

These outcomes point to a possible link between perceived gender discrimination and deteriorating mental wellbeing in women during middle age and beyond, leading the researchers to advocate for intensified efforts to combat gender discrimination. They also highlight the importance of further investigations to better understand this association’s underpinnings and overcome the study’s limitations, including its lack of diversity among participants.

The researchers concluded: “Our findings reveal that middle-aged and older women who experienced perceived sexism were more susceptible to depression and loneliness compared to those who did not perceive sexism. Additionally, these women indicated lower levels of life satisfaction and poor quality of life. The enduring negative impact of gender-based discrimination on mental health and wellbeing observed six years later raises significant concerns.”

More information: Ruth A. Hackett et al, The relationship between gender discrimination and wellbeing in middle-aged and older women, PLoS ONE. DOI: 10.1371/journal.pone.0299381

Journal information: PLoS ONE Provided by PLOS

A few cups of coffee daily may help prevent Parkinson’s disease in individuals at increased risk

According to research by the National Neuroscience Institute, individuals with Asian gene variants associated with Parkinson’s disease (PD) who regularly consume tea or coffee have a substantially lower risk—four to eight times less—of developing the condition compared to those who do not consume caffeine but carry the PD genes. Caffeine consumers with the PD gene have a lower risk of developing PD than non-caffeine consumers without the gene.

Professor Tan Eng King, the study’s Principal Investigator, Deputy Chief Executive Officer (Academic Affairs), and Senior Consultant at the Department of Neurology, National Neuroscience Institute, emphasized that caffeine has a known potential protective effect against PD and other neurodegenerative conditions. The study highlights its significant impact in reducing PD risk, thus balancing the risk levels for Asians who are genetically predisposed to PD but are currently without symptoms.

Professor Tan announced these findings at the 10th Singapore International Parkinson Disease and Movement Disorders Symposium. He explained that caffeine is believed to reduce inflammation in brain neurons, which can prevent cell death. However, the specific interactions between caffeine and Asian PD gene variants remain unclear.

The research involved 4,488 participants and found that individuals with specific Asian genetic variants are 1.5 to 2 times more likely to develop PD. These variants are most prevalent among East Asians, with up to 10% of the Singapore population carrying one of these gene variants located in the coding region, which is crucial for protein synthesis.

Participants in the study completed a validated caffeine intake questionnaire. The average caffeine consumption was 448.3 mg among those diagnosed with PD and 473.0 mg among healthy controls. This is equivalent to 4 to 5 cups of Western-style Arabica coffee or 2 cups of traditional Singapore coffee made from Robusta beans, which are higher in caffeine content. The study also noted that higher doses of caffeine seemed to enhance protective benefits, though even those consuming less than 200 mg of caffeine daily saw a reduced risk of PD. Daily 400 mg of caffeine is generally considered safe for most healthy adults.

Parkinson’s disease is the fastest-growing neurodegenerative condition worldwide, with over 8,000 individuals living with PD in Singapore alone. This figure represents only a fraction of the potential cases, as a study by NNI indicated that 26% of the local elderly population show mild Parkinsonian signs. Professor Tan highlighted that these findings represent a significant advance in combatting this debilitating condition.

He stressed the broader implications of this research for PD prevention, particularly in regions like Singapore, where the relevant Asian gene variants are prevalent. In these communities, tea and coffee are widely available and culturally ingrained, offering a simple, enjoyable, and social means for individuals to decrease their PD risk.

More information: Yi-Lin Ong et al, Caffeine intake interacts with Asian gene variants in Parkinson’s disease: a study in 4488 subjects, The Lancet. DOI: 10.1016/j.lanwpc.2023.100877

Journal information: The Lancet Provided by SingHealth