Recent research published in the Journal of the American Heart Association illuminates the promising potential of prioritising heart health and adopting heart-healthy lifestyle practices. Led by Dr Jiantao Ma from Tufts University, the study suggests that regardless of chronological age, adhering to heart-healthy behaviours and effectively managing heart disease risk factors could contribute to a younger biological age and reduce the risk of heart disease, stroke, and mortality from heart-related conditions. These findings inspire, encouraging further exploration into the intricate relationship between heart health, DNA methylation, and healthy ageing.
The investigation focused on whether DNA methylation, a process regulating gene expression, could serve as a mechanism through which cardiovascular health factors influence cellular ageing and mortality risk. Analysing data from over 5,600 adults enrolled in the Framingham Heart Study, researchers utilised the American Heart Association’s Life’s Essential 8 tool to assess cardiovascular health comprehensively. This tool evaluates various behavioural and clinical measures, providing insights into cardiovascular well-being.
Significant findings emerged from the analysis, indicating that each improvement in Life’s Essential 8 score was associated with a notable reduction in the risk of cardiovascular disease, cardiovascular mortality, and all-cause mortality. Interestingly, among individuals genetically predisposed to accelerated biological ageing, adherence to heart-healthy behaviours demonstrated a heightened impact on outcomes, potentially mediated by DNA methylation.
Approximately 20% of the association between Life’s Essential 8 scores and cardiovascular outcomes was attributed to the influence of cardiovascular health factors on DNA methylation. This figure rose to almost 40% for individuals at higher genetic risk. Dr Ma emphasised the importance of prioritising heart health and the eight essential factors the American Heart Association outlined to promote healthy ageing and prevent cardiovascular disease.
Co-author Dr. Randi Foraker underscores the significance of the findings, highlighting DNA methylation’s role as a potential mediator between modifiable risk factors and cardiovascular disease. The study provides not just insights, but actionable strategies for healthy aging and the mitigation of cardiovascular risks. This emphasis on practical implications empowers individuals interested in cardiovascular health and healthy ageing, giving them the tools to take control of their health.
While the study’s retrospective nature and participants’ predominantly European ancestry pose limitations, ongoing efforts to broaden research inclusion aim to explore the relationship between cardiovascular risk factors and DNA methylation across diverse racial and ethnic groups. The findings underscore the urgent need to address cardiovascular risk factors and promote heart-healthy lifestyles to combat the global burden of heart disease and stroke.
More information: Madeleine Carbonneau et al, Epigenetic Age Mediates the Association of Life’s Essential 8 With Cardiovascular Disease and Mortality, Journal of the American Heart Association. DOI: 10.1161/JAHA.123.032743
Journal information: Journal of the American Heart Association Provided by American Heart Association
