Daily Archives: 23 June 2024

Reconsidering the Care of Patients Admitted for Social Reasons

The categorisation of vulnerable hospital patients as “socially admitted” has been identified as potentially obstructing their medical treatment, as indicated by recent research published in the Canadian Medical Association Journal (CMAJ). Emergency departments often serve as a last resort for socially vulnerable individuals who, despite not presenting with acute or newly arising medical conditions, demonstrate remarkable resilience in seeking care due to a breakdown in support systems or the inability of themselves or their families to manage home-based living conditions. Such individuals are colloquially referred to as “social admissions,” and various labels such as “orphan patient” or “failure to cope” have been applied to them.

Dr. Jasmine Mah, an internal medicine resident focusing on geriatrics at Dalhousie University in Halifax, Nova Scotia, and co-authors highlight that “social admission” remains an under-researched area within healthcare. These patients, often perceived by healthcare providers as not acutely ill, face significantly higher in-hospital mortality rates ranging from 22.2% to 34.9%. Contributing factors may include under-triaging in emergency departments due to inadequate recognition of atypical clinical presentations and delays in timely assessments.

Moreover, there is a risk of misdiagnosis or the development of acute illnesses during hospitalisation. Researchers conducted a qualitative study exploring healthcare providers’ perspectives on “social admissions” in Nova Scotia to gain deeper insights into this patient category. They identified nine overarching themes, including stigma, prejudices such as ageism, wait lists, and other factors influencing perceptions and approaches towards caring for these patients.

The authors emphasise the detrimental impact of labelling patients as “socially admitted” or “orphan patients” (as described in the study hospital), citing instances where such labels lead to incorrect assumptions about medical needs and cognitive abilities. This, in turn, hinders efforts to identify and treat underlying medical issues promptly.

The study reveals that such labelling adversely affects patient health and undermines healthcare providers’ morale. Many providers express conflicted feelings about delivering care to these patients, often feeling that others should handle such care. This attitude risks relegating the care of “socially admitted” patients to team members who may lack sufficient experience in recognising evolving medical conditions or advocating effectively for clinical reassessments when necessary. This hierarchical approach underscores a detachment from the specific needs of this patient demographic.

In response to these findings, the authors passionately advocate for structural reforms within healthcare systems to enhance care delivery for vulnerable populations. They call for a reconsideration of current organisational structures and hierarchies, aiming to eliminate barriers that impede optimal care for socially vulnerable individuals. By doing so, they believe that we can create a healthcare system that is more inclusive, compassionate, and effective in meeting the needs of all patients.

In a related editorial published in CMAJ, Dr Catherine Varner, a deputy editor and emergency medicine physician, along with co-authors Dr Andrew Boozary, a primary care physician, and Dr Andreas Laupacis, editor of CMAJ, argue for a reframing of the issue as a policy failure rather than a personal one. They criticise policies such as Ontario’s alternate level of care policies, which penalise hospitals and patients for occupying beds despite no longer requiring acute care. Such punitive measures, they argue, not only cause distress among patients, families, and providers but also fail to address the root causes of hospital overcrowding.

Instead, they propose embedding collaborative and supportive programmes within healthcare settings, such as multidisciplinary geriatric teams in emergency departments and health teams dedicated to supporting vulnerable populations. These initiatives aim to enhance the management of frail older patients and provide comprehensive support to socially vulnerable individuals, restoring dignity and improving outcomes in healthcare delivery.

Ultimately, the authors stress the paramount importance of addressing structural factors contributing to health disparities as systemic failures rather than individual shortcomings. They call for a paradigm shift towards policies that not only address the complex needs of vulnerable patient populations but also uphold and restore human dignity. This, they argue, is the key to alleviating moral distress among healthcare providers and improving overall healthcare outcomes.

More information: Jasmine C. Mah et al, Managing “socially admitted” patients in hospital: a qualitative study of health care providers’ perceptions, Canadian Medical Association Journal. DOI: 10.1503/cmaj.231430

Journal information: Canadian Medical Association Journal

Implementing Mindfulness Practices in the Workplace to Mitigate Stress and Burnout

A groundbreaking study by researchers at the University of Nottingham’s Schools of Psychology and Medicine has revealed compelling evidence of the relationship between mindfulness and well-being in the digital workplace. The study, based on responses from 142 employees, found that those who practice mindfulness in their digital work environments experience a significant reduction in stress, anxiety, and overload. Published in PLOS ONE, these findings underscore the crucial role of mindfulness in managing the challenges of modern work settings.

Leading the research from the School of Psychology, PhD student Elizabeth Marsh spearheaded a study that aimed to understand the impact of digital technology on individuals’ health and propose effective strategies. Marsh’s insights, “As digital technology increasingly shapes our work, our study aimed to understand its health implications and identify strategies. Our results underscore the need for integrating digital mindfulness and confidence into a healthy digital work-life balance in the 21st century.” This underscores the importance of promoting mindfulness practices in organisations to support employee well-being in the face of digital advancements.

Survey respondents shared perspectives on the challenges posed by the digital workplace, including stress, overload, anxiety, fear of missing out, and addiction, and how these factors influence their health. The study revealed that employees with higher digital confidence exhibited lower susceptibility to digital workplace anxiety. Moreover, those demonstrating elevated levels of mindfulness showed greater resilience against these adversities. Insights from 14 interviews further highlighted how cultivating digital mindfulness can safeguard well-being, presenting a promising avenue for intervention.

Dr. Alexa Spence, Associate Professor of Psychology, highlighted the role of digital workplace technologies in exacerbating employees’ stress perceptions. “Technologies like e-mail, instant messaging, and mobile devices contribute significantly to employees’ stress perceptions,” she observed. “The rapid evolution of the digital workplace can heighten stress levels and potentially lead to burnout and deteriorating health.” This underscores the urgency for organisations to confront digital technology challenges and implement strategies to mitigate their impact on employee well-being.

Mindfulness, defined as intentional and non-judgmental present-moment awareness, emerges as a critical factor in alleviating the negative effects of the digital workplace. Employees with higher mindfulness levels demonstrate reduced vulnerability to the adverse impacts of digital work environments. Professor Elvira Perez Vallejos, a leading authority in Digital Technology for Mental Health, reiterated the implications of the research, stating, “Organisations must actively address digital workplace hazards alongside other psychosocial and physical risks. Fostering mindful awareness among employees engaged in digital work has immense potential to enhance overall well-being.” This underscores the transformative potential of mindfulness interventions in bolstering employee resilience and well-being in the digital era, offering a beacon of optimism for the future.

More information: Elizabeth Marsh et al, Mindfully and confidently digital: A mixed methods study on personal resources to mitigate the dark side of digital working, PLoS ONE. DOI: 10.1371/journal.pone.0295631

Journal information: PLoS ONE Provided by University of Nottingham

Study Reveals Accelerated Ageing of Specific Brain Cells Linked to Alzheimer’s Disease

University of California San Diego engineers have uncovered significant insights into brain cell aging and its implications for Alzheimer’s disease. Their research, published in Nature, utilised the revolutionary MUSIC (multinucleic acid interaction mapping in single cells) technique. This groundbreaking approach delved into the molecular complexities within individual brain cells, offering unprecedented insights into how these dynamics change as brain cells age.

The study, spearheaded by Professor Sheng Zhong from the UC San Diego Jacobs School of Engineering, highlighted a striking finding: specific brain cells exhibit accelerated ageing processes, particularly in individuals affected by Alzheimer’s disease. Notably, the research unveiled sex-specific disparities in ageing patterns, with the female cortex demonstrating a higher prevalence of “old” oligodendrocytes compared to “old” neurons, contrasting with observations in the male cortex.

MUSIC proved instrumental in these discoveries by enabling researchers to analyse postmortem brain samples, specifically from human frontal cortex tissues. Samples were sourced from 14 donors aged 59 years and older, encompassing Alzheimer’s-afflicted individuals and healthy counterparts. This meticulous analysis revealed distinct patterns of chromatin-RNA interactions across various brain cell types. Remarkably, cells exhibiting fewer short-range chromatin interactions tended to show signs of ageing and Alzheimer’s disease pathology.

“This transformative single-cell technology allowed us to identify discrepancies in cellular ageing,” remarked Professor Zhong, underscoring how Alzheimer’s patients displayed more of these aged brain cells than healthy controls.

The implications of this research are profound, suggesting potential avenues for targeted therapeutic interventions. By identifying dysregulated genes within these aged cells and elucidating their roles in local chromatin structures, researchers hope to pinpoint novel therapeutic targets. Xingzhao Wen, a bioinformatics Ph.D. candidate involved in the study, underscored the potential of these findings: understanding the functions of these dysregulated genes could pave the way for innovative treatments aimed at mitigating brain aging and combating neurodegenerative diseases.

Moreover, the study illuminated gender-specific nuances in brain cell ageing dynamics. In female mice, the cortex exhibited a disproportionately higher ratio of aged oligodendrocytes relative to aged neurons. Oligodendrocytes play a crucial role in neuronal insulation and function maintenance; thus, their increased prevalence in an aged state could potentially exacerbate cognitive decline and contribute to heightened susceptibility to neurodegenerative disorders among women. This finding underscores the urgency of addressing gender disparities in neurodegenerative diseases.

“This finding sheds new light on the elevated risks of neurodegenerative conditions observed in women,” noted Wen, highlighting the need for further research to elucidate the underlying mechanisms driving these sex-specific disparities.

Looking ahead, the team aims to refine the MUSIC technique further to identify specific regulatory genes and gene circuits responsible for accelerated ageing in distinct brain cell populations. By understanding these mechanisms in greater detail, they hope to devise strategies to mitigate brain ageing and develop targeted therapies for Alzheimer’s disease and related conditions.

The implications of this research are profound, offering a new paradigm for understanding brain ageing and neurodegenerative diseases. By harnessing the power of MUSIC and similar cutting-edge technologies, scientists are poised to unlock unprecedented insights into the molecular underpinnings of Alzheimer’s disease, potentially transforming how we diagnose, treat, and ultimately prevent cognitive decline associated with ageing. Professor Zhong aptly summarised, “This technology has the potential to revolutionise our understanding of Alzheimer’s pathology and pave the way for personalised therapeutic strategies aimed at improving patient outcomes.”

More information: Xingzhao Wen et al, Single-cell multiplex chromatin and RNA interactions in ageing human brain, Nature. DOI: 10.1038/s41586-024-07239-w

Journal information: Nature Provided by University of California San Diego

Enhanced Walking Ability in Peripheral Artery Disease Patients with Over-the-Counter Supplement

The over-the-counter supplement nicotinamide riboside, a type of vitamin B3, demonstrated significant improvement in walking endurance for patients with peripheral artery disease (PAD), a chronic condition of the legs with limited effective treatments. A preliminary, randomised, double-blind clinical trial by scientists from Northwestern University and the University of Florida revealed that participants who took nicotinamide riboside daily for six months increased their timed walking distance by more than 57 feet compared to those on a placebo. In contrast, participants on the placebo experienced a decline in walking speed, consistent with the progressive nature of PAD affecting walking performance.

“This study suggests nicotinamide riboside could be beneficial for these patients,” noted Christiaan Leeuwenburgh, PhD, a senior author of the trial report and a professor at the University of Florida specialising in physiology and ageing. The collaboration with Mary M. McDermott, M.D., a professor at Northwestern University and an expert in PAD, involved a comprehensive team effort, and their findings were published in the journal Nature Communications on June 13.

Ninety participants, with an average age of 71 and diagnosed with PAD, were recruited for the study to evaluate the effects of nicotinamide riboside. While the supplement has gained popularity in anti-ageing treatments, with U.S. sales exceeding $60 million in 2022, its benefits have been poorly supported by evidence in healthy individuals. Nicotinamide riboside is a precursor to NAD, an essential compound in energy production, enhanced blood flow, and DNA repair processes within the body.

Given that PAD hampers energy generation in muscle cells, McDermott and Leeuwenburgh hypothesised that nicotinamide riboside’s capacity to boost energy production could alleviate walking difficulties associated with the disease. The results supported their hypothesis, demonstrating that participants who adhered to the supplement regimen saw an average increase of 23 feet in their six-minute walking test over six months, while those on placebo experienced a decline of 34 feet. Participants who consistently took at least 75% of the prescribed nicotinamide riboside pills achieved even more significant improvements, adding over 100 feet to their walking distance compared to placebo recipients.

PAD affects more than 8.5 million Americans aged 40 and older, primarily due to arterial fatty deposits compounded by conditions like diabetes and smoking, leading to reduced blood flow to the legs and resultant pain during walking. While supervised walking exercise is the primary therapy for PAD, access to such programmes remains limited for most patients.

Looking ahead, Leeuwenburgh aims to expand their research with more extensive trials focused on PAD patients and to investigate nicotinamide riboside’s impact on walking performance in healthy older adults. “Before recommending nicotinamide riboside for healthy individuals, we must first test its effects in this population,” he emphasised, highlighting the need for further exploration into its broader potential benefits beyond disease-specific contexts.

More information: Mary M. McDermott et al, Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial, Nature Communications. DOI: 10.1038/s41467-024-49092-5

Journal information: Nature Communications Provided by University of Florida