Scientists at The University of Queensland have unveiled a breakthrough finding from an edible mushroom known for its capacity to enhance nerve growth and improve memory. Led by Professor Frederic Meunier of the Queensland Brain Institute, the research team pinpointed novel active compounds within the Hericium erinaceus mushroom, commonly referred to as lion’s mane mushroom. This mushroom has been recognized for its brain cell growth and memory enhancement capabilities in pre-clinical evaluations, as reported by the university.
Professor Meunier explained that lion’s mane mushrooms, long utilized in traditional Asian medicine, were studied to scientifically verify their effects on brain cells. The pre-clinical experiments demonstrated that these mushrooms notably boost brain cell growth and memory enhancement. Through laboratory examinations, the team observed that the isolated compounds from Hericium erinaceus significantly encourage the formation of neuron projections, which play a critical role in neuron connectivity and communication.
Employing advanced super-resolution microscopy techniques, the researchers discovered that extracts from the mushroom, along with its active components, substantially enlarged growth cones. These growth cones are essential for brain cells to navigate their surroundings and connect with other brain neurons, facilitating cognitive functions and memory.
Dr Ramon Martinez-Marmol, a study co-author from UQ, highlighted the potential of this discovery in treating and safeguarding against neurodegenerative cognitive conditions, including Alzheimer’s disease. The team’s objective was to find naturally occurring bioactive compounds capable of crossing the blood-brain barrier to stimulate neuron growth and enhance memory formation.
Dr. Dae Hee Lee of CNGBio Co, a collaborator and supporter of the research project, emphasized the historical use of lion’s mane mushrooms in traditional Chinese medicine for healing and health maintenance. The research sheds light on the molecular mechanisms behind the cognitive benefits of lion’s mane mushroom compounds, particularly in memory enhancement.
The findings were published in the Journal of Neurochemistry, acknowledging the joint efforts with researchers from South Korea’s Gachon University and Chungbuk National University. This study reaffirms the medicinal value of lion’s mane mushrooms and opens new avenues for developing treatments for cognitive disorders.
More information: Ramón Martínez-Mármol et al, Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory, Journal of Neurochemistry. DOI: 10.1111/jnc.15767
Journal information: Journal of Neurochemistry Provided by University of Queensland
